{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:31:29Z","timestamp":1790735489061,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T00:00:00Z","timestamp":1528329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81702708"],"award-info":[{"award-number":["81702708"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2018,9]]},"abstract":"Objective<\/jats:title>Although previous evidence indicates that CD<\/jats:styled-content>147 is closely involved in the progression of organ fibrosis and various signaling pathways have been proven to regulate its expression, the role of CD<\/jats:styled-content>147 in oral submucous fibrosis (OSF<\/jats:styled-content>) remains largely unknown.<\/jats:p><\/jats:sec>Methods<\/jats:title>In this study, we investigated the expression of CD<\/jats:styled-content>147 and transforming growth factor \u03b21 (TGF<\/jats:styled-content>\u2010\u03b21) in human samples of an OSF<\/jats:styled-content> tissue array by immunohistopathology. Pearson's correlation analysis was conducted to explore the correlation between CD<\/jats:styled-content>147 and TGF<\/jats:styled-content>\u2010\u03b21. Immunofluorescence and Western blotting were used to investigate to levels of CD<\/jats:styled-content>147 in Human Oral Keratinocytes (HOK<\/jats:styled-content>s) followed by TGF<\/jats:styled-content>\u2010\u03b21 or LY<\/jats:styled-content>2157299, an inhibitor of TGF<\/jats:styled-content>\u2010\u03b21 receptor and arecoline stimulation.<\/jats:p><\/jats:sec>Results<\/jats:title>We found that CD<\/jats:styled-content>147 was highly expressed in both HOK<\/jats:styled-content>s and the fibrotic oral mucosa and that this expression was correlated with TGF<\/jats:styled-content>\u2010\u03b21 expression. Additionally, CD<\/jats:styled-content>147 levels were significantly associated with the fibrosis stage. The TGF<\/jats:styled-content>\u2010\u03b21 signaling pathway was found to be mainly responsible for CD<\/jats:styled-content>147 up\u2010regulation after arecoline treatment whereas inhibition of TGF<\/jats:styled-content>\u2010\u03b21 down\u2010regulated CD<\/jats:styled-content>147 expression.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our findings suggest arecoline promotes CD<\/jats:styled-content>147 expression via the TGF<\/jats:styled-content>\u2010\u03b21 signaling pathway in HOK<\/jats:styled-content>s, whereas overexpression of CD<\/jats:styled-content>147 may promote OSF<\/jats:styled-content> progression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12845","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T18:21:47Z","timestamp":1519237307000},"page":"993-1000","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Experimental study on TGF<\/scp>\u2010\u03b21\u2010mediated CD<\/scp>147 expression in oral submucous fibrosis"],"prefix":"10.1111","volume":"24","author":[{"given":"W","family":"Wang","sequence":"first","affiliation":[{"name":"Center for Medical Genetics School of Life Sciences Central South University Changsha Hunan China"},{"name":"Centre of Stomatology Xiangya Hospital Central South University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Xiong","sequence":"additional","affiliation":[{"name":"Center for Medical Genetics School of Life Sciences Central South University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Hu","sequence":"additional","affiliation":[{"name":"Center for Medical Genetics School of Life Sciences Central South University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Zhao","sequence":"additional","affiliation":[{"name":"Center for Medical Genetics School of Life Sciences Central South University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Hu","sequence":"additional","affiliation":[{"name":"Centre of Stomatology Xiangya Hospital Central South University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Chen","sequence":"additional","affiliation":[{"name":"Centre of Stomatology Xiangya Hospital Central South University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Han","sequence":"additional","affiliation":[{"name":"Centre of Stomatology Xiangya Hospital Central South University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Yang","sequence":"additional","affiliation":[{"name":"Centre of Stomatology Xiangya Hospital Central South University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Hu","sequence":"additional","affiliation":[{"name":"Centre of Stomatology Xiangya Hospital Central South University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Wang","sequence":"additional","affiliation":[{"name":"Centre of Stomatology Xiangya Hospital Central South University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Mao","sequence":"additional","affiliation":[{"name":"Centre of Stomatology Xiangya Hospital Central South University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Xia","sequence":"additional","affiliation":[{"name":"Center for Medical Genetics School of Life Sciences Central South University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7466-3999","authenticated-orcid":false,"given":"T","family":"Su","sequence":"additional","affiliation":[{"name":"Centre of Stomatology Xiangya Hospital Central South University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12582"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.100594"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200405-612OC"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.9.22.14048"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.174037"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(01)00738-0"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(86)90112-3"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-016-0334-7"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2017.07.003"},{"key":"e_1_2_8_11_1","first-page":"1","article-title":"Betel\u2010quid and areca\u2010nut chewing and some areca\u2010nut derived nitrosamines","volume":"85","author":"Humans","year":"2004","journal-title":"IARC monographs on the evaluation of carcinogenic risks to humans"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3353\/omp.15.21"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2004.01.005"},{"key":"e_1_2_8_14_1","first-page":"1","article-title":"Sub Mucous fibrosis of the palate and pillars","volume":"4","author":"Joshi S. G.","year":"1953","journal-title":"Indian Journal of Otolaryngology"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2011.01960.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2010.10.009"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep16552"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1006\/mgme.2000.3032"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2015.04.013"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2008.08.017"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1985.tb00468.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(96)00115-X"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195605\/06)9:3<431::AID-CNCR2820090302>3.0.CO;2-T"},{"key":"e_1_2_8_24_1","series-title":"Histological Typing of Odontogenic Tumours, Jaw Cysts, and Allied Lesions","volume-title":"International Histological Classification of Tumors","author":"Pindborg J. J.","year":"1972"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.4317\/jced.51318"},{"key":"e_1_2_8_26_1","first-page":"568","article-title":"Betel\u2010nut chewing and submucous fibrosis in Durban","volume":"74","author":"Seedat H. A.","year":"1988","journal-title":"South African Medical Journal"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161212802083734"},{"key":"e_1_2_8_28_1","first-page":"2276","article-title":"Regulation of MMP\u20101 and MMP\u20102 production through CD147\/extracellular matrix metalloproteinase inducer interactions","volume":"61","author":"Sun J.","year":"2001","journal-title":"Cancer research"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1600355"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.306686"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2016.04.003"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2005.08.005"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119723"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.3815"},{"key":"e_1_2_8_35_1","first-page":"467","article-title":"Fibrosis, a common pathway to organ failure: Angiotensin II and tissue repair","volume":"17","author":"Weber K. T.","year":"1997","journal-title":"Seminars in nephrology"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2016.89"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.149"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.12.017"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20140823"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12570"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.07.042"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2008.06.010"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fodi.12845","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.12845","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T01:17:53Z","timestamp":1694999873000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.12845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,7]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1111\/odi.12845"],"URL":"https:\/\/doi.org\/10.1111\/odi.12845","archive":["Portico"],"relation":{},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,7]]},"assertion":[{"value":"2017-12-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}