{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T18:48:49Z","timestamp":1777488529596,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T00:00:00Z","timestamp":1527552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81060085"],"award-info":[{"award-number":["81060085"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2018,9]]},"abstract":"Objectives<\/jats:title>To observe relationships between oral Candida<\/jats:italic> status and salivary human beta\u2010defensin 2 and 3 (hBD<\/jats:styled-content>\u20102 and hBD<\/jats:styled-content>\u20103) levels in HIV<\/jats:styled-content>\/AIDS<\/jats:styled-content> patients of Guangxi, China during the first year of antiretroviral therapy (ART<\/jats:styled-content>) dynamically, and to understand the influence of ART<\/jats:styled-content> on oral Candida<\/jats:italic> status and salivary hBD<\/jats:styled-content>s expressions.<\/jats:p><\/jats:sec>Methods<\/jats:title>A prospective self\u2010controlled study was carried to observe the dynamic changes of CD<\/jats:styled-content>4+<\/jats:sup> T cell counts, oral Candida<\/jats:italic> carriages and salivary hBD<\/jats:styled-content>\u20102,3 expressions in HIV<\/jats:styled-content>\/AIDS<\/jats:styled-content> patients during the first year of ART<\/jats:styled-content>. A total of 90 HIV<\/jats:styled-content>\/AIDS<\/jats:styled-content> patients were enrolled and were examined at the baseline, 3rd, 6th, 12th month of ART<\/jats:styled-content>. Thirty healthy individuals were enrolled as control. Peripheral blood, oral rinse sample, and unstimulated whole saliva were collected to test CD<\/jats:styled-content>4+<\/jats:sup> T cell counts, oral Candida<\/jats:italic> carriages, and hBD<\/jats:styled-content>\u20102,3 expressions.<\/jats:p><\/jats:sec>Results<\/jats:title>In the first year of ART<\/jats:styled-content>, CD<\/jats:styled-content>4+<\/jats:sup> T cell counts increased significantly. However, oral Candida<\/jats:italic> carriages and oral candidiasis decreased significantly, and salivary hBD<\/jats:styled-content>\u20102 expressions in HIV<\/jats:styled-content>\/AIDS<\/jats:styled-content> patients decreased gradually, salivary hBD<\/jats:styled-content>\u20103 levels were highly variable. Salivary hBD<\/jats:styled-content>\u20102 concentrations were positively related to oral Candida<\/jats:italic> carriages.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The incidence of oral candidiasis among HIV<\/jats:styled-content>\/AIDS<\/jats:styled-content> patients gradually decreased due to the immune reconstruction of ART<\/jats:styled-content>. Salivary defensins might play an important role in Candida<\/jats:italic>\u2010host interaction in HIV<\/jats:styled-content>\/AIDS<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12847","type":"journal-article","created":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T16:33:12Z","timestamp":1520008392000},"page":"964-971","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Salivary human beta\u2010defensins affected by oral Candida<\/i> status in Chinese HIV<\/scp>\/AIDS<\/scp> patients undergoing ART<\/scp>"],"prefix":"10.1111","volume":"24","author":[{"given":"Z","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Periodontics and Oral Medicine College of Stomatology Guangxi Medical University Nanning Guangxi China"},{"name":"Guangxi Key Laboratory of AIDS Prevention and Treatment Guangxi Medical University Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X","family":"Yong","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine College of Stomatology Guangxi Medical University Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine College of Stomatology Guangxi Medical University Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine College of Stomatology Guangxi Medical University Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine College of Stomatology Guangxi Medical University Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention (CDC) Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine College of Stomatology Guangxi Medical University Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4299-1231","authenticated-orcid":false,"given":"R","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine College of Stomatology Guangxi Medical University Nanning Guangxi China"},{"name":"Guangxi Key Laboratory of AIDS Prevention and Treatment Guangxi Medical University Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,29]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"AIDS(2017).Guidelines for prevention and treatment of opportunistic infections in HIV\u2010infected adults and adolescents. 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