{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T01:29:46Z","timestamp":1789867786610,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T00:00:00Z","timestamp":1527552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the levels of antithyroid antibodies and thyroid hormones in the sera of patients with oral lichen planus (<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>), and to quantify the expression of thyroid proteins in <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Venous blood samples were drawn from 110 patients with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> who had no history of thyroid disease or levothyroxine supplementation (<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>+\/<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content><jats:sub>4<\/jats:sub>\u2212). A random population sample of 657 healthy subjects was used as the control group. Two additional groups were used as comparators. Immunohistochemical and <jats:styled-content style=\"fixed-case\">qPCR<\/jats:styled-content> analyses were performed on tissue specimens collected from the patients with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> and thyroid disease and healthy subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No association was found between the presence of antithyroid antibodies and <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>. More patients in the <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>+\/<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content><jats:sub>4<\/jats:sub>\u2212 group showed high levels of thyroid\u2010stimulating hormone and low levels of free thyroxine than were seen in the control group. Thyroid\u2010stimulating hormone receptor was more highly expressed in the <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> lesions of patients with thyroid disease than in the healthy oral mucosa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A significant number of patients with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> who are not previously diagnosed with thyroid disease have thyroid parameters that are compatible with hypothyroidism. The expression of thyroid\u2010stimulating hormone receptor in <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> lesions suggests that mechanisms related to autoimmune thyroid disease are involved in the aetiology of <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12850","type":"journal-article","created":{"date-parts":[[2018,3,3]],"date-time":"2018-03-03T02:22:42Z","timestamp":1520043762000},"page":"1001-1011","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["A mechanistic linkage between oral lichen planus and autoimmune thyroid disease"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6120-8655","authenticated-orcid":false,"given":"J","family":"Robledo\u2010Sierra","sequence":"first","affiliation":[{"name":"Department of Oral Medicine and Pathology Institute of Odontology Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Landin\u2010Wilhelmsen","sequence":"additional","affiliation":[{"name":"Institute of Medicine Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Endocrinology Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Filipsson Nystr\u00f6m","sequence":"additional","affiliation":[{"name":"Institute of Medicine Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Endocrinology Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Eggertsen","sequence":"additional","affiliation":[{"name":"Institute of Medicine Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Primary Health Care Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Larsson","sequence":"additional","affiliation":[{"name":"Department of Periodontology Institute of Odontology Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Dafar","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Pathology Institute of Odontology Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Warfvinge","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Malm\u00f6 University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U","family":"Mattsson","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Pathology Institute of Odontology Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Jontell","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Pathology Institute of Odontology Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.257"},{"issue":"25","key":"e_1_2_8_3_1","first-page":"e21","article-title":"Oral lichen planus and oral lichenoid lesions: Diagnostic and therapeutic considerations","volume":"103","author":"Al\u2010Hashimi I.","year":"2007","journal-title":"Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/1807-3107bor-2017.vol31.0010"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-0496"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1430639"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2006.04.010"},{"issue":"1","key":"e_1_2_8_8_1","first-page":"48","article-title":"Significantly higher frequencies of presence of serum autoantibodies in Chinese patients with oral lichen planus","volume":"38","author":"Chang J. 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