{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T12:17:22Z","timestamp":1788956242590,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T00:00:00Z","timestamp":1528329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001734","name":"K\u00f8benhavns Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001734","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:label\/><jats:p>Some patients with oral lichen planus (<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>) experience recurrent oral candidiasis(<jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>). Probiotic bacteria have shown to reduce the oral <jats:italic>Candida<\/jats:italic> count in vivo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study whether probiotic intervention reduces recurrent <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Twenty\u2010two patients with symptomatic <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> were enrolled in the double\u2010blinded, randomized, placebo\u2010controlled intervention study. Lozenges containing <jats:italic>Lactobacilli reuteri<\/jats:italic> (<jats:styled-content style=\"fixed-case\">DSM<\/jats:styled-content> 17938 and <jats:styled-content style=\"fixed-case\">ATCC PTA<\/jats:styled-content> 5289) or placebo were dissolved intra\u2010orally three times daily for 16\u00a0weeks, after which patients were followed up for 36\u00a0weeks. Mucosal symptoms, <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content> pain, <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> severity score, plaque index (<jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>) and gingival index (<jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>), <jats:italic>Candida<\/jats:italic> count\/carriage, and <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content> and\/or need for symptomatic treatment were registered. Statistical significance was set at <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No difference was observed between the groups during the intervention or follow\u2010up in terms of recurrent <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content> (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.966) or need for symptomatic treatment (<jats:italic>p<\/jats:italic>\u00a0=\u00a01.000). There was no difference in terms of <jats:italic>Candida<\/jats:italic> count (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.96) or carriage over time (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.511). <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> decreased in the probiotic group and increased in the placebo group (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.046). <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> severity score decreased in both groups during the study period (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.039). Across the entire study period, the placebo group had higher <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content> pain score (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.037).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Probiotic intervention did not reduce recurrent <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content> or <jats:italic>Candida<\/jats:italic> count\/carriage, but the study experienced recruitment problems, which may have influenced results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12858","type":"journal-article","created":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T19:27:39Z","timestamp":1521833259000},"page":"1107-1114","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Randomized pilot study on probiotic effects on recurrent candidiasis in oral lichen planus patients"],"prefix":"10.1111","volume":"24","author":[{"given":"MK","family":"Keller","sequence":"first","affiliation":[{"name":"Department of Odontology Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0892-4972","authenticated-orcid":false,"given":"C","family":"Kragelund","sequence":"additional","affiliation":[{"name":"Department of Odontology Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,7]]},"reference":[{"issue":"36","key":"e_1_2_9_2_1","first-page":"1","article-title":"A prevalence study of oral mucosal lesions in an adult Swedish population","volume":"27","author":"Axell T.","year":"1976","journal-title":"Odontologisk Revy. 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