{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T12:28:10Z","timestamp":1777292890313,"version":"3.51.4"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T00:00:00Z","timestamp":1523318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470033"],"award-info":[{"award-number":["81470033"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31371279"],"award-info":[{"award-number":["31371279"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>Hereditary dentin disorders include dentinogenesis imperfecta (<jats:styled-content style=\"fixed-case\">DGI<\/jats:styled-content>) and dentin dysplasia (<jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content>), which are autosomal dominant diseases characterized by altered dentin structure such as abnormality in dentin mineralization and the absence of root dentin. Shields classified<jats:styled-content style=\"fixed-case\">DGI<\/jats:styled-content>into three subgroups and<jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content>into two subtypes. Although they are all hereditary dentin diseases, they do not share the same causative genes. To date, the pathogenic genes of<jats:styled-content style=\"fixed-case\">DGI<\/jats:styled-content>type I, which is considered a clinical manifestation of syndrome osteogenesis imperfecta, include<jats:italic><jats:styled-content style=\"fixed-case\">COL<\/jats:styled-content>1A1<\/jats:italic>and<jats:italic><jats:styled-content style=\"fixed-case\">COL<\/jats:styled-content>1A2<\/jats:italic>. Mutations of the<jats:italic><jats:styled-content style=\"fixed-case\">DSPP<\/jats:styled-content><\/jats:italic>gene, which encodes the dentin sialophosphoprotein, a major non\u2010collagenous protein, are responsible for three isolated dentinal diseases:<jats:styled-content style=\"fixed-case\">DGI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">DGI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>, and<jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>. However,<jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content>\u2010I appears to be special in that researchers have found three pathogenicity genes\u2015<jats:italic><jats:styled-content style=\"fixed-case\">VPS<\/jats:styled-content>4B<\/jats:italic>,<jats:italic><jats:styled-content style=\"fixed-case\">SSUH<\/jats:styled-content>2<\/jats:italic>, and<jats:italic><jats:styled-content style=\"fixed-case\">SMOC<\/jats:styled-content>2\u2015<\/jats:italic>in three affected families from different countries. It is believed that<jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content>\u2010I is a genetically heterogeneous disease and is distinguished from other types of dentin disorders. This review summarizes the<jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content>\u2010I literature in the context of clinical appearances, radiographic characteristics, and functions of its pathogenic genes and aims to serve clinicians in further understanding and diagnosing this disease.<\/jats:p>","DOI":"10.1111\/odi.12861","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T18:36:32Z","timestamp":1522002992000},"page":"439-446","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Dentin dysplasia type I\u2014A dental disease with genetic heterogeneity"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9627-4895","authenticated-orcid":false,"given":"D","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Stomatology The First Affiliated Hospital of Zhengzhou University Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9291-6176","authenticated-orcid":false,"given":"X","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Stomatology The First Affiliated Hospital of Zhengzhou University Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Stomatology The First Affiliated Hospital of Zhengzhou University Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Stomatology The First Affiliated Hospital of Zhengzhou University Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics School of Basic Medical Sciences Southern Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Stomatology The First Affiliated Hospital of Zhengzhou University Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2012.12.008"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.11.002"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(02)00361-7"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-010-9197-3"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(91)90202-N"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1754-4505.1983.tb01615.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2009.07.015"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2013.05.003"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-013-9989-5"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2014.159"},{"issue":"1","key":"e_1_2_11_12_1","first-page":"65","article-title":"Dental findings of hyperphosphatemic familial tumoral calcinosis","volume":"33","author":"Erbudak H.","year":"2016","journal-title":"Oral Radiology"},{"issue":"152","key":"e_1_2_11_13_1","first-page":"158","article-title":"Oral problems and the dentist's role in the management of paediatric oncology patients","volume":"19","author":"Fayle S. 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