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This highly sophisticated nature of the oral cavity poses a significant therapeutic challenge. Numerous human and animal studies have been conducted to potentiate the efficacy and competence of current treatments of pathologic conditions as well as to develop novel therapeutic modalities. One of these studies is the use of the potent antimicrobial agent lactoferrin (\n                    <jats:styled-content style=\"fixed-case\">LF<\/jats:styled-content>\n                    ), which was originally derived from the host immune system.\n                    <jats:styled-content style=\"fixed-case\">LF<\/jats:styled-content>\n                    is an 80\u2010kDa glycoprotein that has a free iron sequestration mechanism with evident antimicrobial, anti\u2010tumor, and immunomodulatory properties. A wide range of active peptides have been isolated from the N\u2010terminal region of\n                    <jats:styled-content style=\"fixed-case\">LF<\/jats:styled-content>\n                    , which possess antimicrobial activities. In this review, we discuss the role of\n                    <jats:styled-content style=\"fixed-case\">LF<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">LF<\/jats:styled-content>\n                    \u2010derived peptides under a heterogeneous group of oral and maxillofacial conditions, including bacterial, fungal, viral infections; head and neck cancers; xerostomia; and implantology\u2010bone\u2010related manifestations.\n                  <\/jats:p>","DOI":"10.1111\/odi.12868","type":"journal-article","created":{"date-parts":[[2018,4,14]],"date-time":"2018-04-14T21:09:02Z","timestamp":1523740142000},"page":"652-669","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Role of lactoferrin and lactoferrin\u2010derived peptides in oral and maxillofacial diseases"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6739-6511","authenticated-orcid":false,"given":"K","family":"Velliyagounder","sequence":"first","affiliation":[{"name":"Department of Oral Biology Rutgers School of Dental Medicine  Newark New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Bahdila","sequence":"additional","affiliation":[{"name":"Department of Oral Biology Rutgers School of Dental Medicine  Newark New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Pawar","sequence":"additional","affiliation":[{"name":"Department of Oral Biology Rutgers School of Dental Medicine  Newark New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DH","family":"Fine","sequence":"additional","affiliation":[{"name":"Department of Oral Biology Rutgers School of Dental Medicine  Newark New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,7]]},"reference":[{"key":"e_1_2_15_2_1","first-page":"35","article-title":"Lactoferrin interaction with Actinobacillus actinomycetemcomitans","volume":"10","author":"Afugupalli K.","year":"1995","journal-title":"Molecular Oral Microbiology"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.1998.tb01146.x"},{"key":"e_1_2_15_4_1","article-title":"Diabetic lactoferrin deficient mice demonstrates greater susceptibility to experimental periodontal disease","volume":"2","author":"Alabdulmohsen W.","year":"2015","journal-title":"Journal of Oral Biology"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.17796\/1053-4628-39.3.255"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.3923\/pjbs.2009.91.94"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1995.tb01091.x"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1996.tb08579.x"},{"key":"e_1_2_15_9_1","first-page":"174","article-title":"Effect of lactoferrin on interaction of Prevotella intermedia with plasma and subepithelial matrix proteins","volume":"9","author":"Alugupalli K.","year":"1994","journal-title":"Molecular Oral Microbiology"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-83242013000100004"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2014.04.010"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-3542(02)00214-0"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01597-07"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2007.00586.x"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.327545"},{"key":"e_1_2_15_16_1","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1128\/iai.35.3.792-799.1982","article-title":"Bactericidal activity of human lactoferrin: Differentiation from the stasis of iron deprivation","volume":"35","author":"Arnold R. 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