{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T22:53:57Z","timestamp":1767480837412,"version":"3.37.3"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,6,8]],"date-time":"2018-06-08T00:00:00Z","timestamp":1528416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["U01\u2010DE\u2010018993"],"award-info":[{"award-number":["U01\u2010DE\u2010018993"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81102178","81573225"],"award-info":[{"award-number":["81102178","81573225"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["7172115"],"award-info":[{"award-number":["7172115"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Multiple studies have suggested nonsyndromic cleft lip with or without cleft palate (NSCL\/P), and lung cancer may have common genetic etiology. Previous studies have showed genetic variants in nicotinic cholinergic receptor genes (<jats:italic>CHRNs<\/jats:italic>) may influence risk of lung cancer. We aimed to explore the effect of <jats:italic>CHRNs<\/jats:italic> on risk of NSCL\/P considering gene\u2013gene (GxG) interaction for these genes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>We selected 120 markers in 14 <jats:italic>CHRNs<\/jats:italic> to test for GxG interaction using 806 Chinese case\u2013parent trios recruited from an international consortium established for a GWAS of oral clefts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Totally, two pairs of SNPs yielded significant GxG interactions after Bonferroni correction (rs935865 and rs2337980 with <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>4.04\u00a0\u00d7\u00a010<jats:sup>\u22125<\/jats:sup>, rs2741335 and rs3743077 with <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>4.80\u00a0\u00d7\u00a010<jats:sup>\u22124<\/jats:sup>), and these pairwise interactions were confirmed in permutation tests. In addition, the relative risk (RR) of the putative interaction between rs935865 and rs2337980 was 1.10 (95% CI: 0.92~1.31).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>While the single SNP association and the gene\u2013environment interaction analysis of 14 <jats:italic>CHRN<\/jats:italic> genes yielded no signal, this study did demonstrate the importance of considering potential GxG interaction for exploring etiology of NSCL\/P. This study suggests an important role for particular combinations of SNPs in <jats:italic>CHRN<\/jats:italic> genes in influencing risk to NSCL\/P, which needs further study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12879","type":"journal-article","created":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T15:12:58Z","timestamp":1524582778000},"page":"1068-1072","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluating the effect of nicotinic cholinergic receptor genes on the risk of nonsyndromic cleft lip with or without cleft palate"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0162-5355","authenticated-orcid":false,"given":"Mengying","family":"Wang","sequence":"first","affiliation":[{"name":"School of Public Health Peking University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongjing","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Public Health Peking University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Schwender","sequence":"additional","affiliation":[{"name":"Mathematical Institute Heinrich Heine University Duesseldorf  Duesseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Public Health Peking University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0069-5458","authenticated-orcid":false,"given":"Ping","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Center for Disease Prevention and Control  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhibo","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Stomatology Peking University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"School of Stomatology Peking University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Public Health Peking University  Beijing China"},{"name":"Key Laboratory of Reproductive Health Ministry of Health  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongping","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Stomatology Peking University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terri H.","family":"Beaty","sequence":"additional","affiliation":[{"name":"School of Public Health Johns Hopkins University  Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.109"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.9503.1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.580"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.20595"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwi132"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2012.01.004"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2008.02.011"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.571"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1597\/05-167"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.20.2463"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gdata.2016.08.017"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31541"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06885"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.34430"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.9870"},{"key":"e_1_2_8_17_1","first-page":"2862","article-title":"A multi\u2010ethnic genome\u2010wide association study identifies novel loci for non\u2010syndromic cleft lip with or without cleft palate on 2p24.2, 17q23 and 19q13","volume":"25","author":"Leslie E. 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