{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:30:38Z","timestamp":1787063438460,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T00:00:00Z","timestamp":1527552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2018,10]]},"abstract":"Abstract<\/jats:title>\n \n Objectives<\/jats:title>\n \n Depth of invasion was added to the eighth edition American Joint Committee on Cancer guidelines for T staging of\n HPV<\/jats:styled-content>\n \u2010negative oral cavity squamous cell carcinoma. Our aim was to determine the impact of depth of invasion on pathological variables and outcomes in low\u2010stage tongue cancer patients. We also examine the impact of tumor thickness and tumor clinical staging for comparison.\n <\/jats:p>\n <\/jats:sec>\n \n Subjects and Methods<\/jats:title>\n \n All clinical T1\/T2 N0\n HPV<\/jats:styled-content>\n \u2010negative tongue squamous cell carcinoma patients who received elective neck dissections at our institution between 2000 and 2015 were included. Logistic regression models and Cox proportional hazard models were used to examine pathological variables, recurrence, and 3\u2010year disease\u2010free survival.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Sixty\u2010seven patients met criteria; the mean age was 52.0 (\n SD<\/jats:italic>\n : 17.7). Depth of invasion was a significant predictor of occult metastasis (\n OR<\/jats:styled-content>\n : 2.0,\n p<\/jats:italic>\n \u00a0=\u00a00.05) and lymphovascular invasion (\n OR<\/jats:styled-content>\n : 4.1,\n p<\/jats:italic>\n \u00a0=\u00a00.02), and tumor thickness was a significant predictor of lymphovascular invasion (\n OR<\/jats:styled-content>\n : 3.3,\n p<\/jats:italic>\n \u00a0=\u00a00.04). None of the variables were predictive of recurrence or disease\u2010free survival.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Depth of invasion at biopsy may be a potential useful metric to inform on regional management selection in this radiographic node\u2010negative population.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/odi.12887","type":"journal-article","created":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T16:35:35Z","timestamp":1526056535000},"page":"1198-1203","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Depth of invasion on pathological outcomes in clinical low\u2010stage oral tongue cancer patients"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3477-9898","authenticated-orcid":false,"given":"Maheer M.","family":"Masood","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\/Head and Neck Surgery University of North Carolina at Chapel Hill School of Medicine Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas R.","family":"Farquhar","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\/Head and Neck Surgery University of North Carolina at Chapel Hill School of Medicine Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica P.","family":"Vanleer","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of North Carolina at Chapel Hill School of Medicine Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samip N.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\/Head and Neck Surgery University of North Carolina at Chapel Hill School of Medicine Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor G.","family":"Hackman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\/Head and Neck Surgery University of North Carolina at Chapel Hill School of Medicine Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23380"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(00)00042-7"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-2870-4"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2012.01.015"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.1548"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-0985-4"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26229"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2009.10.011"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.03.009"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.06.139"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2009.01.004"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2006.05.004"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2015.0719"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21389"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.11.007"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20275"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1054\/ijom.2002.0383"},{"issue":"11","key":"e_1_2_9_19_1","first-page":"2559","article-title":"A prospective study of prognostic factors for recurrence in early oral tongue cancer","volume":"7","author":"Sharma P.","year":"2013","journal-title":"Journal of Clinical and Diagnostic Research"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000343796"}],"container-title":["Oral 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