{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T10:30:29Z","timestamp":1759228229377,"version":"3.37.3"},"reference-count":62,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,6,11]],"date-time":"2018-06-11T00:00:00Z","timestamp":1528675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Research Fund of Istanbul University","award":["52756"],"award-info":[{"award-number":["52756"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Parathyroid hormone (<jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>) enhances bone healing. Strontium ranelate (<jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content>) is an antiresorptive agent that increases bone formation. Reports about combined effects of <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content> on local bone regeneration in osteoporotic subjects are limited. We aimed at investigating the efficacy of <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content> for promoting new bone formation in critical\u2010sized defects of ovariectomized rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Parathyroid hormone\u2010 and\/or <jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content>\u2010containing poloxamer implant tablets with\/without chitosan microparticles were delivered locally to calvarial defects of 90 Wistar rats. Biopsies were analyzed histologically and histomorphometrically at 4 and 8\u00a0weeks of healing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Histomorphometry revealed that <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> alone promoted new bone formation at 4\u00a0weeks but the efficiency declined in 8\u00a0weeks. There was no positive effect of <jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content> alone on bone formation at 4 or 8\u00a0weeks. Calvarial defects treated with <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content> combinations showed statistically significant greater new bone formation than either treatment alone at both time intervals. Tissue responses were modest and supported the good biocompatibility of the biomaterials used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Parathyroid hormone and <jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content> combinations can be effective for calvarial bone regeneration of ovariectomized rats. <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> plus <jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content> may have potential use as bone graft material in orthopedic and dental surgery to enhance bone healing and osseointegration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12895","type":"journal-article","created":{"date-parts":[[2018,5,18]],"date-time":"2018-05-18T09:13:58Z","timestamp":1526634838000},"page":"1255-1269","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Combined effect of parathyroid hormone and strontium ranelate on bone healing in ovariectomized rats"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2354-361X","authenticated-orcid":false,"given":"Funda","family":"G\u00f6ker","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche Istituto Ortopedico Galeazzi I.R.C.C.S. 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