{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T12:43:43Z","timestamp":1782996223882,"version":"3.54.5"},"reference-count":45,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,6,8]],"date-time":"2018-06-08T00:00:00Z","timestamp":1528416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The study aimed to investigate the pattern of oral yeast colonization of Sj\u00f6gren's syndrome patients and its correlation to salivary flow rates, age, and time of the disease progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Saliva and swab specimens were obtained from 45 patients (primary Sj\u00f6gren's syndrome\u00a0=\u00a015\/ secondary Sj\u00f6gren's syndrome\u00a0=\u00a015\/ healthy controls\u00a0=\u00a015). Yeast species were identified using culture method through chromogenic medium followed by polymerase chain reaction and Sanger sequencing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven species from six different genera were detected. The most prevalent species found was<jats:italic>Candida albicans<\/jats:italic>followed by<jats:italic>Candida tropicalis<\/jats:italic>,<jats:italic>Candida glabrata, Candida parapsilosis,<\/jats:italic>and<jats:italic>Candida krusei<\/jats:italic>. Both groups of Sj\u00f6gren's syndrome showed higher counts of<jats:italic>C.\u00a0albicans<\/jats:italic>(Total and<jats:styled-content style=\"fixed-case\">CFU<\/jats:styled-content>counts) when compared to control group. In contrast, a greater variety of yeast species was identified on samples of the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study showed that<jats:italic>C.\u00a0albicans<\/jats:italic>is the most prevalent yeast, but also that a variety of other yeast species can colonize the oral cavity of Sjogren's syndrome patients. The identification of most of the colonies was not obtained by culturing\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>methods combined.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12896","type":"journal-article","created":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T19:00:54Z","timestamp":1526929254000},"page":"1367-1378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Oral yeast colonization in patients with primary and secondary Sj\u00f6gren's syndrome"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9919-9627","authenticated-orcid":false,"given":"Clarissa Castro Galv\u00e3o","family":"Medeiros","sequence":"first","affiliation":[{"name":"Department of Oral Medicine Pontifical Catholic University of Rio Grande do Sul (PUCRS) Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Gustavo","family":"dos Anjos Borges","sequence":"additional","affiliation":[{"name":"Geobiology Laboratory Institute of Petroleum and Natural Resources Pontifical Catholic University of Rio Grande do Sul (PUCRS) Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0913-477X","authenticated-orcid":false,"given":"Karen","family":"Cherubini","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Pontifical Catholic University of Rio Grande do Sul (PUCRS) Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Gon\u00e7alves","family":"Salum","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Pontifical Catholic University of Rio Grande do Sul (PUCRS) Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Medina da Silva","sequence":"additional","affiliation":[{"name":"Immunology and Microbiology Laboratory Biosciences School Pontifical Catholic University of Rio Grande do Sul (PUCRS) Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Antonia Zancanaro","family":"de Figueiredo","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Pontifical Catholic University of Rio Grande do Sul (PUCRS) Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(98)90151-2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-7-22"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11274-013-1574-z"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-302X.2003.180101.x"},{"key":"e_1_2_8_6_1","first-page":"1007","article-title":"Microflora in oral ecosystems in Primary Sj\u00f6gren's Syndrome","volume":"5","author":"Almstahl A.","year":"2001","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr900478h"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-36341997000500006"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/23.24.4992"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1517-83822014005000040"},{"key":"e_1_2_8_11_1","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1093\/nar\/gkh340","article-title":"Muscle: Multiple sequence alignment with high accuracy and high throughput","volume":"5","author":"Edgar R. 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