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Here, we investigated the responsiveness of submandibular gland when such xenohormone exposure occurs later in life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Chemicals were given <jats:italic>orally<\/jats:italic> to male and female Wistar rats (1\u00a0mg\/kg body weight per day), from weaning to adulthood. Submandibular glands and plasma were collected at postnatal day 100 for histologic and molecular analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Whereas no effect was observed in females, increases in granular convoluted tubules area coupled with a modification of salivary secretions were found in male submandibular glands. Genistein and vinclozolin similarly increased the <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression of Cystatin C, Mucin 10, Growth factors, and plasmatic <jats:styled-content style=\"fixed-case\">EGF<\/jats:styled-content>. Negative correlations were found between the expressions of androgen receptor and <jats:styled-content style=\"fixed-case\">EGF<\/jats:styled-content> (\u22120.34; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05), <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u03b1 (\u22120.52; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01), Mucin 10 (\u22120.43; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05), and Cystatin C (\u22120.42; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) as well as between progesterone receptor and <jats:styled-content style=\"fixed-case\">EGF<\/jats:styled-content> (\u22120.56; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01). The Spearman correlation test revealed also a positive correlation between salivary <jats:styled-content style=\"fixed-case\">EGF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression and <jats:styled-content style=\"fixed-case\">EGF<\/jats:styled-content> in plasma (+0.32; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings confirm the sex\u2010dependent sensitivity of submandibular salivary glands to dietary xenohormones and underline the influence of the exposure period.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12907","type":"journal-article","created":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T16:23:13Z","timestamp":1528129393000},"page":"1235-1246","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Post\u2010weaning xenohormone intake affects adult rat submandibular gland in a sex\u2010dependent manner"],"prefix":"10.1111","volume":"24","author":[{"given":"Wided","family":"Kouidhi","sequence":"first","affiliation":[{"name":"Research Unit no 01\/UR\/08\u201007 Faculty of Medicine Tunis University of Tunis El Manar  Tunis Tunisia"},{"name":"AGROSUP, CNRS, INRA Centre des sciences du Go\u00fbt et de l'Alimentation Universit\u00e9 de Bourgogne Franche comt\u00e9  Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond","family":"Berg\u00e8s","sequence":"additional","affiliation":[{"name":"AGROSUP, CNRS, INRA Centre des sciences du Go\u00fbt et de l'Alimentation Universit\u00e9 de Bourgogne Franche comt\u00e9  Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ga\u00eatan","family":"Drouin","sequence":"additional","affiliation":[{"name":"AGROSUP, CNRS, INRA Centre des sciences du Go\u00fbt et de l'Alimentation Universit\u00e9 de Bourgogne Franche comt\u00e9  Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Desmetz","sequence":"additional","affiliation":[{"name":"AGROSUP, CNRS, INRA Centre des sciences du Go\u00fbt et de l'Alimentation Universit\u00e9 de Bourgogne Franche comt\u00e9  Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Auger","sequence":"additional","affiliation":[{"name":"INSERM U1016, Equipe G\u00e9nomique, Epig\u00e9n\u00e9tique et Physiologie de la Reproduction Institut Cochin Universit\u00e9 Paris Descartes  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mich\u00e8le","family":"El May","sequence":"additional","affiliation":[{"name":"Research Unit no 01\/UR\/08\u201007 Faculty of Medicine Tunis University of Tunis El Manar  Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8594-0576","authenticated-orcid":false,"given":"Marie\u2010Chantal","family":"Canivenc\u2010Lavier","sequence":"additional","affiliation":[{"name":"AGROSUP, CNRS, INRA Centre des sciences du Go\u00fbt et de l'Alimentation Universit\u00e9 de Bourgogne Franche comt\u00e9  Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2017.04.018"},{"key":"e_1_2_8_3_1","volume-title":"The safety and benefits of dietary phytoestrogens \u2013 Recommandations","author":"AFSSA\u2010AFSSAPS","year":"2005"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1003258514766"},{"key":"e_1_2_8_5_1","first-page":"185","article-title":"Submaxillary glands in an endocrine context","volume":"13","author":"Arancibia S.","year":"1985","journal-title":"Journal de Biologie Buccale"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.121.105"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/28.8.7003006"},{"key":"e_1_2_8_8_1","first-page":"656","article-title":"Epidermal growth factor, renin, and peptidase in cultured tumor cells of submandibular gland origin","volume":"42","author":"Barka T.","year":"1980","journal-title":"Laboratory Investigation"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-97-1-189"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf0728045"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1993.tb00208.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2011.01.002"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(08)60101-1"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1986.39"},{"key":"e_1_2_8_15_1","unstructured":"Epa U. 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