{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:17:55Z","timestamp":1787015875787,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T00:00:00Z","timestamp":1531180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003711","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["CNPq 476387\/2010\u20108"],"award-info":[{"award-number":["CNPq 476387\/2010\u20108"]}],"id":[{"id":"10.13039\/501100003711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the effects of periodontal treatment on endothelial function in patients with coronary artery disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      A randomized controlled trial was conducted with 69 patients with stable coronary disease and severe periodontitis. The test group received nonsurgical periodontal therapy consisting of personalized oral hygiene instructions, subgingival scaling, and root planing per quadrant, whereas the control group received equal treatment after the study period. Endothelial function was assessed by measurement of brachial artery flow\u2010mediated dilation, concentrations of\n                      <jats:styled-content style=\"fixed-case\">sVCAM<\/jats:styled-content>\n                      \u20101,\n                      <jats:styled-content style=\"fixed-case\">sICAM<\/jats:styled-content>\n                      \u20101, and P\u2010selectin in serum before and 3\u00a0months after periodontal therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The test group exhibited statistically better periodontal parameters\u2014plaque, probing depth, periodontal attachment loss, and bleeding on probing. No significant improvements were observed in the control (1.37%) and test (1.39%) groups in flow\u2010mediated dilation, with no significant between\u2010group difference.\n                      <jats:styled-content style=\"fixed-case\">sVCAM<\/jats:styled-content>\n                      \u20101 concentration increased in the control group (997.6\u00a0\u00b1\u00a0384.4\u20131201.8\u00a0\u00b1\u00a0412.5;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.03), whereas in the test group, no significant changes were observed (915.1\u00a0\u00b1\u00a0303.8\u20131050.3\u00a0\u00b1\u00a0492.3;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.17), resulting in a significant difference between the two groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.04). The same pattern was observed for concentrations of\n                      <jats:styled-content style=\"fixed-case\">sICAM<\/jats:styled-content>\n                      \u20101.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Periodontal treatment did not provide better vasodilation in patients with coronary disease in a short\u2010term follow\u2010up period, although it maintained blood concentrations of markers of vascular inflammation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.12909","type":"journal-article","created":{"date-parts":[[2018,6,6]],"date-time":"2018-06-06T11:24:56Z","timestamp":1528284296000},"page":"1349-1357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Periodontal therapy and endothelial function in coronary artery disease: A randomized controlled trial"],"prefix":"10.1111","volume":"24","author":[{"given":"Marco Aur\u00e9lio L.","family":"Saffi","sequence":"first","affiliation":[{"name":"Graduate Program in Cardiovascular Sciences: Cardiology Federal University of Rio Grande do Sul (UFRGS)  Porto Alegre Brazil"},{"name":"Department of Cardiology Hospital de Cl\u00ednicas de Porto Alegre (HCPA)  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eneida R.","family":"Rabelo\u2010Silva","sequence":"additional","affiliation":[{"name":"Graduate Program in Cardiovascular Sciences: Cardiology Federal University of Rio Grande do Sul (UFRGS)  Porto Alegre Brazil"},{"name":"Department of Cardiology Hospital de Cl\u00ednicas de Porto Alegre (HCPA)  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carisi A.","family":"Polanczyk","sequence":"additional","affiliation":[{"name":"Graduate Program in Cardiovascular Sciences: Cardiology Federal University of Rio Grande do Sul (UFRGS)  Porto Alegre Brazil"},{"name":"Department of Cardiology Hospital de Cl\u00ednicas de Porto Alegre (HCPA)  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana V.","family":"Furtado","sequence":"additional","affiliation":[{"name":"Graduate Program in Cardiovascular Sciences: Cardiology Federal University of Rio Grande do Sul (UFRGS)  Porto Alegre Brazil"},{"name":"Department of Cardiology Hospital de Cl\u00ednicas de Porto Alegre (HCPA)  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlon M.","family":"Montenegro","sequence":"additional","affiliation":[{"name":"Periodontology Federal University of Rio Grande do Sul, Faculty of Dentistry  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid W. 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