{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:16:35Z","timestamp":1787015795230,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T00:00:00Z","timestamp":1531180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17K11917"],"award-info":[{"award-number":["17K11917"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008541","name":"Japanese Association for Dental Science","doi-asserted-by":"publisher","award":["2016B\u20102"],"award-info":[{"award-number":["2016B\u20102"]}],"id":[{"id":"10.13039\/501100008541","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2018,10]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n \n Primordial odontogenic tumour (\n POT<\/jats:styled-content>\n ) is a rare benign mixed epithelial and mesenchymal odontogenic tumour.\n POT<\/jats:styled-content>\n is composed of dental papilla\u2010like tissue covered with cuboidal to columnar epithelium that resembles to inner and outer enamel epithelium of the enamel organ without dental hard tissue formation. The aim of this study was to examine pathogenesis of\n POT<\/jats:styled-content>\n based on tumourigenesis and odontogenesis.\n <\/jats:p>\n <\/jats:sec>\n \n Subjects and methods<\/jats:title>\n \n Six cases of\n POT<\/jats:styled-content>\n were submitted for study.\n DNA<\/jats:styled-content>\n analysis and transcriptome analysis were performed by next\u2010generation sequencing. Expression of amelogenin, ameloblastin and dentin sialophosphoprotein (\n DSPP<\/jats:styled-content>\n ) was examined by immunohistochemistry.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n There were no gene mutations detected in any of analysed 151 cancer\u2010 and 42 odontogenesis\u2010associated genes. Enamel protein\u2010coding genes of\n Amelx<\/jats:italic>\n ,\n Ambn<\/jats:italic>\n and\n Enam<\/jats:italic>\n , and dentin protein\u2010coding genes of\n Col1a1<\/jats:italic>\n ,\n Dspp<\/jats:italic>\n ,\n Nes<\/jats:italic>\n and\n Dmp1<\/jats:italic>\n were expressed, whereas expression of dentinogenesis\u2010associated genes of\n Bglap<\/jats:italic>\n ,\n Ibsp<\/jats:italic>\n and\n Nfic<\/jats:italic>\n was negative or very weak suggesting inhibition of dentin formation in\n POT<\/jats:styled-content>\n after odontoblast differentiation. Immunoreactivity of amelogenin, ameloblastin and\n DSPP<\/jats:styled-content>\n was detected in\n POT<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Pathogenesis of\n POT<\/jats:styled-content>\n is considered to be genetically different from other odontogenic tumours. It is suggested that inhibition of enamel and dentin formation in\n POT<\/jats:styled-content>\n is due to defects in dentin formation process.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/odi.12914","type":"journal-article","created":{"date-parts":[[2018,6,16]],"date-time":"2018-06-16T09:04:40Z","timestamp":1529139880000},"page":"1226-1234","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Pathogenesis of primordial odontogenic tumour based on tumourigenesis and odontogenesis"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6224-0593","authenticated-orcid":false,"given":"Toshinari","family":"Mikami","sequence":"first","affiliation":[{"name":"Division of Anatomical and Cellular Pathology Department of Pathology Iwate Medical University Yahaba Shiwa\u2010gun Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9755-4779","authenticated-orcid":false,"given":"Ronell","family":"Bologna\u2010Molina","sequence":"additional","affiliation":[{"name":"Molecular Pathology Area Faculty of Dentistry Universidad de la Rep\u00fablica Montevideo Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adalberto","family":"Mosqueda\u2010Taylor","sequence":"additional","affiliation":[{"name":"Health Care Department Universidad Aut\u00f3noma Metropolitana Xochimilco Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuko","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Center of Oral Clinical Examination Hiroshima University Hospital Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanesa","family":"Pereira\u2010Prado","sequence":"additional","affiliation":[{"name":"Molecular Pathology Area Faculty of Dentistry Universidad de la Rep\u00fablica Montevideo Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Division of Functional Morphology Department of Anatomy Iwate Medical University Yahaba Shiwa\u2010gun Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio Ramoa","family":"Pires","sequence":"additional","affiliation":[{"name":"School of Dentistry State University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Carlos","sequence":"additional","affiliation":[{"name":"Pathology Division Centro Cl\u00ednico de Cabeza y Cuello\/Hospital Herrera\u2010Llerandi Guatemala City Guatemala"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Takata","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathobiology Institute of Biomedical and Health Sciences Hiroshima University Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasunori","family":"Takeda","sequence":"additional","affiliation":[{"name":"Division of Clinical Pathology Department of Oral and Maxillofacial Reconstructive Surgery School of Dentistry Iwate Medical University Morioka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12543"},{"key":"e_1_2_8_3_1","volume-title":"Ten Cate's Oral Histology Development, Structure, and Function","author":"Antonio N.","year":"2013"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0909-8836.1998.eos106510.x"},{"issue":"3","key":"e_1_2_8_5_1","first-page":"e314","article-title":"Primordial odontogenic tumor: An immunohistochemical profile","volume":"22","author":"Bologna\u2010Molina R.","year":"2017","journal-title":"Medicina Oral, Patologia Oral y Cirugia Bucal"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12733"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2011.01079.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.07.021"},{"key":"e_1_2_8_9_1","volume-title":"World health organization classification of head and neck tumours","author":"El\u2010Naggar A. 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