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A search of PubMed\/<jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>, Web of Science, and Cochrane Library databases was conducted. Articles were selected based on the inclusion criteria: randomized clinical trials, prospective\/retrospective studies, and case series with at least 10 patients, with a minimum follow\u2010up period of 6\u00a0months. A weighted remission rate (<jats:styled-content style=\"fixed-case\">RER<\/jats:styled-content>) and recurrence rate (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>) with a 95% confidence interval was performed. Data analysis was performed using a comprehensive meta\u2010analysis software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 283 <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>s in 10 studies were included. About 2.5% surgically treated cases underwent malignant transformation. The weighted remission rate was higher for surgical (92.8%) compared to non\u2010surgical treatment (65.9%). The recurrence rate was lower for surgical (8.4%) compared to non\u2010surgical treatment (19.2%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this systematic review, the surgical treatment was more favorable than non\u2010surgical for <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>. Meanwhile, further studies are needed that should maximize methodological standardization and have greater rigor of the data collection process.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12916","type":"journal-article","created":{"date-parts":[[2018,6,16]],"date-time":"2018-06-16T13:18:52Z","timestamp":1529155132000},"page":"972-981","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Surgical versus non\u2010surgical treatment of actinic cheilitis: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6815-5696","authenticated-orcid":false,"given":"Marianne de Vasconcelos","family":"Carvalho","sequence":"first","affiliation":[{"name":"Post\u2010Graduate Dentistry Program School of Dentistry Pernambuco University (UPE)  Camaragibe Pernambuco Brazil"},{"name":"School of Dentistry Pernambuco University (UPE)  Arcoverde Pernambuco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra L\u00facia Dantas","family":"de Moraes","sequence":"additional","affiliation":[{"name":"Post\u2010Graduate Dentistry Program School of Dentistry Pernambuco University (UPE)  Camaragibe Pernambuco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cleidiel Aparecido Araujo","family":"Lemos","sequence":"additional","affiliation":[{"name":"Dental Materials and Prosthodontics School of Dentistry S\u00e3o Paulo State University (UNESP)  Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel Ferreira","family":"Santiago J\u00fanior","sequence":"additional","affiliation":[{"name":"School of Dentistry Sacred Heart University  Bauru S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belmiro Cavalcanti do\u00a0Egito","family":"Vasconcelos","sequence":"additional","affiliation":[{"name":"Post\u2010Graduate Dentistry Program School of Dentistry Pernambuco University (UPE)  Camaragibe Pernambuco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo Piza","family":"Pellizzer","sequence":"additional","affiliation":[{"name":"Dental Materials and Prosthodontics School of Dentistry S\u00e3o Paulo State University (UNESP)  Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2012.01930.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2006.09.003"},{"issue":"5","key":"e_1_2_8_4_1","first-page":"548","article-title":"Laser\u2010mediated photodynamic therapy of actinic cheilitis","volume":"3","author":"Alexiades\u2010Armenakas M. 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