{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:49:18Z","timestamp":1774687758178,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,7,18]],"date-time":"2018-07-18T00:00:00Z","timestamp":1531872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Hs\u2010CRP, fetuin\u2010A, and S100A12 are acute\u2010phase proteins associated with many systemic diseases and conditions. The aim of this study was to determine the clinical parameters and salivary Hs\u2010CRP, fetuin\u2010A, and S100A12 levels before and after nonsurgical periodontal treatments in the patients with periodontal diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 54 subjects were divided into three groups of 18 patients each: periodontally healthy, gingivitis, and chronic periodontitis. Clinical periodontal parameters; salivary Hs\u2010CRP, fetuin\u2010A, and S100A12 levels; and salivary flow rates were evaluated at baseline and a month after the treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fetuin\u2010A and S100A12 were significantly lower and Hs\u2010CRP levels were significantly higher in the chronic periodontitis and gingivitis groups than in the control group at baseline (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.01). For the gingivitis and chronic periodontitis groups, the posttreatment levels of salivary fetuin\u2010A and S100A12 were higher than the baseline levels of the same (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.01). There was a negative correlation between Hs\u2010CRP and fetuin\u2010A and Hs\u2010CRP and S100A12 (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001) and a positive correlation between fetuin\u2010A and S100A12 (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.05) at baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Salivary fetuin\u2010A and S100A12 levels decreased with increasing severity of periodontal disease. These results suggest that salivary fetuin\u2010A may play an important role as a negative acute\u2010phase protein in periodontal diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12927","type":"journal-article","created":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T14:30:14Z","timestamp":1530109814000},"page":"1554-1561","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Salivary fetuin\u2010A, S100A12, and high\u2010sensitivity C\u2010reactive protein levels in periodontal diseases"],"prefix":"10.1111","volume":"24","author":[{"given":"Reyhan","family":"Ersin Kalkan","sequence":"first","affiliation":[{"name":"Department of Periodontology Samsun Public Oral Health Center Samsun Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Figen","family":"\u00d6ng\u00f6z Dede","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry Ordu University Ordu Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ceren","family":"G\u00f6kmeno\u011flu","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry Ordu University Ordu Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5356-3665","authenticated-orcid":false,"given":"Cankat","family":"Kara","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry Ordu University Ordu Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,18]]},"reference":[{"issue":"4","key":"e_1_2_8_2_1","first-page":"229","article-title":"Problems and proposals for recording gingivitis and plaque","volume":"25","author":"Ainamo J. 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