{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T11:32:46Z","timestamp":1781091166746,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,8,14]],"date-time":"2018-08-14T00:00:00Z","timestamp":1534204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15K11287"],"award-info":[{"award-number":["15K11287"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We analysed the correlation between magnetic resonance images of the parotid and submandibular glands and the salivary flow rate in patients with Sj\u00f6gren's syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed magnetic resonance images (heterogeneous signal\u2010intensity distribution and gland volume on T1\u2010 and fat\u2010suppressed T2\u2010weighted images, and multiple high\u2010signal\u2010intensity spots on magnetic resonance sialograms in the parotid and submandibular glands) obtained from 66 patients who were diagnosed with Sj\u00f6gren's syndrome. We evaluated the relationship between these imaging features and their salivary flow rates in stimulated and unstimulated conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that as the disease progressed, both the heterogeneous signal\u2010intensity distribution and the volumes of the parotid and the submandibular glands were significantly related to the stimulated and the unstimulated salivary flow rate. These imaging features were more highly correlated in assessments of the submandibular gland than in those of the parotid gland for both stimulated and unstimulated salivary flow rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Magnetic resonance image features of heterogeneity and smaller volume in the submandibular gland are reliable for predicting hyposalivation related to the progression of Sj\u00f6gren's syndrome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12941","type":"journal-article","created":{"date-parts":[[2018,7,14]],"date-time":"2018-07-14T16:03:57Z","timestamp":1531584237000},"page":"117-125","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Relationship of MR imaging of submandibular glands to hyposalivation in Sj\u00f6gren's syndrome"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9660-8245","authenticated-orcid":false,"given":"Ikuho","family":"Kojima","sequence":"first","affiliation":[{"name":"Department of Oral Diagnosis Tohoku University Graduate School of Dentistry Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis Tohoku University Graduate School of Dentistry Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Iikubo","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis Tohoku University Graduate School of Dentistry Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis Tohoku University Graduate School of Dentistry Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Nishioka","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis Tohoku University Graduate School of Dentistry Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Sasano","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis Tohoku University Graduate School of Dentistry Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-012-2024-2"},{"key":"e_1_2_9_3_1","first-page":"38","article-title":"Study of quantitative oral radioactivity in salivary gland scintigraphy and determination of the clinical stage of Sj\u00f6gren's syndrome","volume":"42","author":"Aung W.","year":"2001","journal-title":"Journal of Nuclear Medicine"},{"key":"e_1_2_9_4_1","first-page":"257","article-title":"Sj\u00f6gren's syndrome: Comparison of assessments with quantitative salivary gland scintigraphy and contrast sialography","volume":"41","author":"Aung W.","year":"2000","journal-title":"Journal of Nuclear Medicine"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-196505000-00001"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.21.5.656"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270205"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780220801"},{"key":"e_1_2_9_9_1","first-page":"21","article-title":"The influence of gland size on the flow rate and composition of human parotid saliva","volume":"44","author":"Dawes C.","year":"1978","journal-title":"Dental Journal"},{"key":"e_1_2_9_10_1","first-page":"116","article-title":"Evaluation of diagnostic parameters from parotid and submandibular dynamic salivary glands scintigraphy and unstimulated sialometry in Sj\u00f6gren's syndrome","volume":"17","author":"Dugonjic S.","year":"2014","journal-title":"Hellenic Journal of Nuclear Medicine"},{"key":"e_1_2_9_11_1","first-page":"411","article-title":"Variability of the submandibular flow rate in man with special reference to the size of the gland","volume":"23","author":"Ericson S.","year":"1972","journal-title":"Odontologisk Revy"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-004-0338-x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/003591576205500619"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(74)90417-4"},{"key":"e_1_2_9_15_1","first-page":"557","article-title":"Selection and interpretation of diagnostic tests and procedures. 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