{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:39:17Z","timestamp":1787585957544,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T00:00:00Z","timestamp":1534896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate and compare the therapeutic response of lycopene and curcumin with placebo in patients suffering from oral submucous fibrosis (OSMF) and to correlate the habit variables of smoked and smokeless tobacco products in OSMF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomized placebo\u2010controlled parallel clinical study was conducted on ninety OSMF patients, who were divided into three treatment groups using computer\u2010generated randomization. Group A patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a030) were given curcumin tablet (300\u00a0mg) twice daily, Group B patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a030) received lycopene capsules (8\u00a0mg) twice daily, and for Group C (<jats:italic>n<\/jats:italic>\u00a0=\u00a030), placebo capsules were given once daily for a period of six months. Both the participant and outcome assessor were blinded. Pre\u2010 and post\u2010treatment comparison of mouth opening, burning sensation, tongue protrusion, and cheek flexibility was analyzed at periodic follow\u2010up of 9\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall improvement in mouth opening, burning sensation, tongue protrusion, and cheek flexibility was 3.9\u00a0\u00b1\u00a04.9\u00a0mm, 4.8\u00a0\u00b1\u00a02.6, 5.0\u00a0\u00b1\u00a07.2\u00a0mm, &amp; 0.36\u00a0\u00b1\u00a00.71\u00a0mm, respectively, for curcumin and 4.1\u00a0\u00b1\u00a04.2\u00a0mm, 5.0\u00a0\u00b1\u00a02.3, 2.4\u00a0\u00b1\u00a03.5\u00a0mm, &amp; 0.66\u00a0\u00b1\u00a00.80\u00a0mm, respectively, for lycopene with the <jats:italic>p<\/jats:italic> value &lt;0.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Statistically significant improvement in clinical findings was observed in both curcumin and lycopene treatment groups in comparison with placebo. However, the therapeutic efficacy of curcumin and lycopene was found to be almost equal in OSMF patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12947","type":"journal-article","created":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T14:49:17Z","timestamp":1532962157000},"page":"73-79","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Comparison of therapeutic response of lycopene and curcumin in oral submucous fibrosis: A randomized controlled trial"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9101-2212","authenticated-orcid":false,"given":"Prerna","family":"Piyush","sequence":"first","affiliation":[{"name":"Department of Oral Medicine &amp; Radiology Maulana Azad Institute of Dental Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anshul","family":"Mahajan","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine &amp; Radiology Maulana Azad Institute of Dental Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khushboo","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine &amp; Radiology Maulana Azad Institute of Dental Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujoy","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine &amp; Radiology Maulana Azad Institute of Dental Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunita","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine &amp; Radiology Maulana Azad Institute of Dental Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1482.119353"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(93)90005-P"},{"issue":"2","key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.4103\/0972-1363.166922","article-title":"Comparative study of the efficacy of curcumin and turmeric oil as chemopreventive agents in oral submucous fibrosis: A clinical and histopathological evaluation","volume":"22","author":"Deepa A. 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