{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:32:49Z","timestamp":1790267569893,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T00:00:00Z","timestamp":1537488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department of Odontology, Health and Medical Sciences, University of Copenhagen, Denmark"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Several recent studies have investigated the oral bacteriome in oral lichen planus (OLP), but longitudinal changes in microbiome have not been investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study the bacteriome and mycobiome in OLP over a 1\u2010year period and the impact of topical treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Samples from 22 symptomatic OLP patients from a double\u2010blinded, randomized intervention study were collected over a 1\u2010year course at five visits. Bacterial and fungal abundances were investigated through lesional cytobrush (CB) and full mouthwash (MW). Initially, all patients received conventional (antimycotic or steroid) and probiotic or placebo treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The microbial composition differed between the MW and CB samples. During the study period, the microbial composition was individual, with pronounced variability between visits. Patients grouped according to initial conventional treatment. During the study period, unidirectional change in the bacteriome was seen in the antimycotic group, whereas the mycobiome was stable. <jats:italic>Malassezia restricta<\/jats:italic> was the most abundant fungus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The microbial composition of MW and CB differs in OLP. CB composition is less influenced by conventional and probiotic intervention. Initial antimycotic treatment influenced the bacteriome during the 1\u2010year period. How the oral microbiome in health and disease is influenced by individual variability of fungi and bacteria, and <jats:italic>Malassezia<\/jats:italic> needs further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12961","type":"journal-article","created":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T13:19:50Z","timestamp":1535116790000},"page":"327-338","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The oral microbiome in oral lichen planus during a 1\u2010year randomized clinical trial"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0892-4972","authenticated-orcid":false,"given":"Camilla","family":"Kragelund","sequence":"first","affiliation":[{"name":"Department of Odontology, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4241-5792","authenticated-orcid":false,"given":"Mette Kirstine","family":"Keller","sequence":"additional","affiliation":[{"name":"Department of Odontology, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0132783"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1016\/j.tripleo.2006.11.001","article-title":"Oral lichen planus and oral lichenoid lesions: Diagnostic and therapeutic considerations","volume":"103","author":"Al\u2010Hashimi I.","year":"2007","journal-title":"Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics"},{"issue":"36","key":"e_1_2_9_4_1","first-page":"1","article-title":"A prevalence study of oral mucosal lesions in an adult Swedish population","volume":"27","author":"Axell T.","year":"1976","journal-title":"Odontologisk Revy. 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