{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T18:35:31Z","timestamp":1767897331114,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T00:00:00Z","timestamp":1537142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002460","name":"Chung-Ang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002460","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011512","name":"National Research Foundation","doi-asserted-by":"publisher","award":["2018R1D1A1B07043416"],"award-info":[{"award-number":["2018R1D1A1B07043416"]}],"id":[{"id":"10.13039\/100011512","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>There is limited evidence regarding the appropriate length of a bisphosphonate (BP) holiday to reduce the risk of osteonecrosis of the jaw (ONJ). In this cross\u2010sectional study, we investigated the population\u2010based patterns of the gaps between BP discontinuation and ONJ diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>We used the claims database of the National Health Insurance Service in Korea. Among BP users between 2006 and 2015, incident ONJ cases during 2010\u20132015 with no history of ONJ in the last 4\u00a0years were identified. We assessed the time gap from the last BP administration to ONJ diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 1,569 incident ONJ cases, 836 (53.3%) occurred after BP discontinuation. The cumulative proportions of ONJ occurrence within 1\u00a0month, 3\u00a0months, 1\u00a0year, 2\u00a0years, and 3\u00a0years after discontinuation were 58.9%, 70.8%, 87.0%, 93.2%, and 96.1%, respectively. The length of drug holidays showed no significant difference between patients with or without comorbid cancer and diabetes mellitus (<jats:italic>p<\/jats:italic>\u2010value, 0.12 and 0.52, respectively). However, the use of injectable BP formulations significantly affected ONJ incidence (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Most ONJ cases occurred within 3\u00a0years from BP suspension, with a higher prevalence among BP injection users with 1\u00a0year or lesser BP holiday.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12966","type":"journal-article","created":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T17:19:13Z","timestamp":1535476753000},"page":"471-480","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Drug holiday patterns and bisphosphonate\u2010related osteonecrosis of the jaw"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2032-112X","authenticated-orcid":false,"given":"Sun\u2010Young","family":"Jung","sequence":"first","affiliation":[{"name":"College of Pharmacy Chung\u2010Ang University  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3445-6607","authenticated-orcid":false,"given":"Hae Sun","family":"Suh","sequence":"additional","affiliation":[{"name":"College of Pharmacy Pusan National University  Pusan South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0776-4209","authenticated-orcid":false,"given":"Ji\u2010Won","family":"Park","sequence":"additional","affiliation":[{"name":"College of Natural Science Kyungpook National University  Daegu South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3467-7805","authenticated-orcid":false,"given":"Jin\u2010Won","family":"Kwon","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute of Pharmaceutical Sciences Kyungpook National University  Daegu South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2918"},{"issue":"4","key":"e_1_2_8_3_1","first-page":"266","article-title":"Role of bone\u2010modifying agents in multiple myeloma: American society of clinical oncology clinical practice guideline update","volume":"14","author":"Anderson K.","year":"2018","journal-title":"Journal of Clinical Oncology"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.8670"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S37664"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.24.2927"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon.13.211"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/dj4040045"},{"key":"e_1_2_8_9_1","first-page":"33","article-title":"Bisphosphonate\u2010related osteonecrosis of the jaws: A potential alternative to drug holidays","volume":"61","author":"Damm D. 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