{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T13:23:43Z","timestamp":1788009823969,"version":"build-2784847793"},"reference-count":62,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T00:00:00Z","timestamp":1540857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004202","name":"Ondokuz Mayis \u00dcniversitesi","doi-asserted-by":"publisher","award":["PYO.DIS.1904.12.001"],"award-info":[{"award-number":["PYO.DIS.1904.12.001"]}],"id":[{"id":"10.13039\/501100004202","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Vitamin D deficiency is a frequent health problem worldwide, especially as fewer people spend much time in the sun. Vitamin D deficiency is linked to several infectious and inflammatory conditions, including periodontal disease. However, its role in aggressive periodontitis (AgP) has not been well studied. We evaluated the association between vitamin D concentration and periodontal disease, both AgP and chronic (CP) periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method and Materials<\/jats:title><jats:p>Forty\u2010seven AgP 55 CP and 27 control subjects participated. All patients were tested for serum vitamin D concentration (25(OH)D), parathyroid hormone, and serum bone\u2010related biomarkers (alkaline phosphatases, calcium, and phosphorus) regulated by vitamin D.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patients with AgP had lower serum 25(OH)D concentration (11.22\u00a0\u00b1\u00a04.8\u00a0ng\/ml) than controls (16.9\u00a0\u00b1\u00a06.4\u00a0ng\/ml) and patients with CP (16.13\u00a0\u00b1\u00a08.3\u00a0ng\/ml; overall<jats:italic>p<\/jats:italic>value 0.0002). These associations remained significant after adjustment for age and gender (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.002). No significant differences were observed in any bone\u2010related biomarker among the three groups, and no association was observed with periodontal disease indices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest that vitamin D deficiency may be a potential risk factor for AgP. Given the high prevalence of vitamin D deficiency in AgP patients, routine screening for vitamin D status may be advisable in these subjects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12968","type":"journal-article","created":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T17:08:53Z","timestamp":1535735333000},"page":"242-249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Vitamin D deficiency in patients with aggressive periodontitis"],"prefix":"10.1111","volume":"25","author":[{"given":"Emrah","family":"Anbarcioglu","sequence":"first","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine Ondokuz May\u0131s University Samsun Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tugrul","family":"Kirtiloglu","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine Ondokuz May\u0131s University Samsun Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4260-5978","authenticated-orcid":false,"given":"Ayla","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine Ondokuz May\u0131s University Samsun Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filiz","family":"Kolbakir","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine Ondokuz May\u0131s University Samsun Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6khan","family":"Ac\u0131kg\u00f6z","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine Ondokuz May\u0131s University Samsun Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramis","family":"Colak","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, School of Medicine Ondokuz May\u0131s University Samsun Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-016-0288-7"},{"issue":"4","key":"e_1_2_7_3_1","first-page":"229","article-title":"Problems and proposals for recording gingivitis and plaque","volume":"25","author":"Ainamo J.","year":"1975","journal-title":"International Dental Journal"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12436"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2310\/JIM.0b013e31821b8755"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-57-6-1308"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100384"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.6439"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12266"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/396541"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00151"},{"issue":"1","key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1093\/ajcn\/80.1.108","article-title":"Association between serum concentrations of 25\u2010hydroxyvitamin D3 and periodontal disease in the US population","volume":"80","author":"Dietrich T.","year":"2004","journal-title":"The American Journal of Clinical Nutrition"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/82.3.575"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-303934"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2011.172155"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3758\/BRM.41.4.1149"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100207"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.1999.1012"},{"key":"e_1_2_7_20_1","volume-title":"Periodontal disease and overall health: A clinician\u2019s guide","author":"Genco R. 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