{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:06:49Z","timestamp":1790348809762,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T00:00:00Z","timestamp":1541635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001702","name":"AO Foundation","doi-asserted-by":"publisher","award":["AOCMF 14\u2010070"],"award-info":[{"award-number":["AOCMF 14\u2010070"]}],"id":[{"id":"10.13039\/501100001702","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001702","name":"AO Foundation","doi-asserted-by":"publisher","award":["AOCMF 64\u2010210"],"award-info":[{"award-number":["AOCMF 64\u2010210"]}],"id":[{"id":"10.13039\/501100001702","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The management of maxillary medication\u2010related osteonecrosis of the jaw (MRONJ) is challenging. Therefore, identifying the proper treatment is important. This study aimed to evaluate the surgical treatment of maxillary MRONJ using single\u2010layer closure with mucoperiosteal flap and double\u2010layer closure with buccal fat pad flap (BFPF) and mucoperiosteal flap and to find the outcomes after rehabilitation with obturators.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis was conducted and included all surgically treated and followed\u2010up maxillary MRONJ cases in a single center. Demographics and clinical data, stage of MRONJ, surgical treatment, and treatment outcome were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010nine lesions were included. Removal of necrotic bone was followed by coverage with mucoperiosteal flap in 60 lesions and BFPF in 14 lesions. Seven lesions (five primarily and two following unsuccessful treatment with BFPF) underwent necrectomy and were reconstructed with obturators. Complete mucosal healing was achieved in 76.7% of the lesions covered with mucoperiosteal flap. BFPF led to complete mucosal healing in 85.7% of the lesions. No complications were observed in the defects rehabilitated with obturators.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Removal of necrotic bone followed by closure with mucoperiosteal flap is reliable for MRONJ treatment. BFPF is effective for closure of MRONJ\u2010related oroantral communications (OACs).<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12992","type":"journal-article","created":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T13:34:08Z","timestamp":1539696848000},"page":"497-507","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Surgical treatment of medication\u2010related osteonecrosis of the upper jaw: Case series"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4169-6046","authenticated-orcid":false,"given":"Suad","family":"Aljohani","sequence":"first","affiliation":[{"name":"Department of Oral\u2010 and Maxillofacial Surgery Ludwig\u2010Maximilians\u2010University Munich Germany"},{"name":"Department of Oral Basic &amp; Clinical Sciences King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Troeltzsch","sequence":"additional","affiliation":[{"name":"Department of Oral\u2010 and Maxillofacial Surgery Ludwig\u2010Maximilians\u2010University Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigurd","family":"Hafner","sequence":"additional","affiliation":[{"name":"Department of Oral\u2010 and Maxillofacial Surgery Ludwig\u2010Maximilians\u2010University Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Kaeppler","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Radiology, Clinic for Oral and Craniomaxillofacial Surgery Ludwig\u2010Maximilians\u2010University Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerson","family":"Mast","sequence":"additional","affiliation":[{"name":"Department of Oral\u2010 and Maxillofacial Surgery Ludwig\u2010Maximilians\u2010University Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Otto","sequence":"additional","affiliation":[{"name":"Department of Oral\u2010 and Maxillofacial Surgery Ludwig\u2010Maximilians\u2010University Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2004.10.014"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2015.06.165"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prosdent.2015.08.002"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2016.12.014"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.01.006"},{"issue":"6","key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1097\/SCS.0000000000001075","article-title":"Reconstruction of intraoral maxillary defect with buccal fat pad","volume":"25","author":"Chaudhary B.","year":"2014","journal-title":"The Journal of Craniofacial Surgery"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jopr.12157"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/0103-6440201301918"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758-3284-3-28"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0503(77)80117-3"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tec.2009.0487"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.17422"},{"key":"e_1_2_8_14_1","unstructured":"Groetz K. 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