{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:16:45Z","timestamp":1787015805540,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,1,6]],"date-time":"2019-01-06T00:00:00Z","timestamp":1546732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chronic ulcerative stomatitis (CUS) is an immune\u2010mediated disorder characterized by oral erosions and ulcers usually refractory to conventional treatments. The disease often involves middle\u2010aged and older women with painful lesions sometimes resembling those of erosive oral lichen planus (OLP). The most affected sites are the buccal mucosa, the gingiva and the tongue, but the skin is involved in 22.5% of cases. Histopathologic features in CUS are non\u2010specific and indistinguishable from those of OLP, with the exception of the presence of a mixed infiltrate composed of lymphocytes and plasma cells. Direct immunofluorescence (DIF) analysis reveals the presence of stratified epithelium\u2010specific antinuclear antibodies (SES\u2010ANA) in the lower third of the epithelium. The IgG antibodies detected on DIF are directed against the \u2206Np63\u03b1 isoform of p63 expressed in the nuclei of the epithelial basal cells. A distinguishing feature of CUS is the low response to conventional corticosteroid therapy and the good outcome with hydroxychloroquine at the dosage of 200\u00a0mg\/day or higher dosages. This paper presents a comprehensive review of CUS and is accompanied by a new case report (the 73rd case) and a proposal for updated diagnostic criteria.<\/jats:p>","DOI":"10.1111\/odi.13001","type":"journal-article","created":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T06:53:47Z","timestamp":1542696827000},"page":"1465-1491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Chronic ulcerative stomatitis: A comprehensive review and proposal for diagnostic criteria"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2532-7651","authenticated-orcid":false,"given":"Lorenzo","family":"Azzi","sequence":"first","affiliation":[{"name":"Unit of Oral Pathology, Dental Clinic, ASST Sette Laghi, Ospedale di Circolo, Department of Medicine and Surgery University of Insubria Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Cerati","sequence":"additional","affiliation":[{"name":"Unit of Anatomical Pathology, ASST Sette Laghi Ospedale di Circolo Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Lombardo","sequence":"additional","affiliation":[{"name":"Unit of Dermatological Diseases, ASST Sette Laghi Ospedale di Circolo Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Pellilli","sequence":"additional","affiliation":[{"name":"Unit of Anatomical Pathology, ASST Sette Laghi Ospedale di Circolo Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Croveri","sequence":"additional","affiliation":[{"name":"Unit of Oral Pathology, Dental Clinic, ASST Sette Laghi, Ospedale di Circolo, Department of Medicine and Surgery University of Insubria Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7386-4956","authenticated-orcid":false,"given":"Vittorio","family":"Maurino","sequence":"additional","affiliation":[{"name":"Unit of Oral Pathology, Dental Clinic, ASST Sette Laghi, Ospedale di Circolo, Department of Medicine and Surgery University of Insubria Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4233-8427","authenticated-orcid":false,"given":"Angelo","family":"Tagliabue","sequence":"additional","affiliation":[{"name":"Unit of Oral Pathology, Dental Clinic, ASST Sette Laghi, Ospedale di Circolo, Department of Medicine and Surgery University of Insubria Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1558-5729","authenticated-orcid":false,"given":"Lucia","family":"Tettamanti","sequence":"additional","affiliation":[{"name":"Unit of Oral Pathology, Dental Clinic, ASST Sette Laghi, Ospedale di Circolo, Department of Medicine and Surgery University of Insubria Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2744-8353","authenticated-orcid":false,"given":"Malgorzata","family":"Olszewska","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical University of Warsaw Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2017.08.008"},{"key":"e_1_2_8_3_1","first-page":"400","article-title":"Przewlekle wrzodziej\u0105ce zapalenie jamy ustnej. 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