{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T08:54:51Z","timestamp":1771664091111,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T00:00:00Z","timestamp":1545177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Sciences Foundation of China","doi-asserted-by":"crossref","award":["81000445"],"award-info":[{"award-number":["81000445"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Sciences Foundation of China","doi-asserted-by":"crossref","award":["81771083"],"award-info":[{"award-number":["81771083"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Fibrosis diseases are one of the leading causes of suffering and death. However, no systematic investigation has been carried out on fibrosis\u2010related genes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>By querying PubMed using keywords \u201cfibrosis\u201d and \u201cgene\u201d or \u201cprotein,\u201d we identified fibrosis\u2010related genes in the last decade. Bioinformatics analysis was performed by MAS 3.0 software. Key miRNA was selected to assess its relationship with oral submucous fibrosis (OSF) and fibroblast functions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1,310 genes related to fibrosis were identified. <jats:italic>TGF\u2010\u03b21, CTGF, MMP9, HSP47, and S1P<\/jats:italic> were found to be associated with mainly fibrotic organs. In total, 244 cellular components terms, 595 molecular function terms, 1,816 cellular component terms, and 136 KEGG pathway annotations were predicted. miR\u2010199\u20105p was selected as the key miRNA, which has higher level in OSF. Upregulated miR\u2010199\u20105p was significantly related to OSF duration and OSF histological grade (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.028 and 0.012, respectively). Overexpressive miR\u2010199\u20105p reduced proliferation and induced apoptosis in buccal fibroblasts. Additionally, expression levels of collagen I (COL I) and III (COL III) were promoted by overexpressive miR\u2010199\u20105p in buccal fibroblasts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results indicate that fibrosis\u2010related genes are related to a series of complex mechanisms. The characteristics of miR\u2010199\u20105p may supply important clues for developing therapeutic strategy for OSF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13008","type":"journal-article","created":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T18:49:53Z","timestamp":1543430993000},"page":"456-465","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Pathogenesis investigation of miR\u2010199\u20105p in oral submucous fibrosis based on bioinformatics analysis"],"prefix":"10.1111","volume":"25","author":[{"given":"Yongxiang","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Xiangya Hospital Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3726-0773","authenticated-orcid":false,"given":"Ning","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Xiangya Hospital Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijuan","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Xiangya Hospital Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengzhong","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Xiangya Hospital Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Canhua","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Xiangya Hospital Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00141.2011"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12581"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003291"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12431"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23922"},{"key":"e_1_2_9_7_1","first-page":"96","article-title":"Fibrosis\u2013a common pathway to organ injury and failure","volume":"373","author":"Don C. 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