{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:49:25Z","timestamp":1747187365323,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T00:00:00Z","timestamp":1545177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Science Funds of China","award":["81600849","81271118"],"award-info":[{"award-number":["81600849","81271118"]}]},{"name":"National Precision Medicine Project","award":["2016YFC0905203"],"award-info":[{"award-number":["2016YFC0905203"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2019,3]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>Genome\u2010wide association studies (GWAS) found NTN1<\/jats:italic>, NOG<\/jats:italic> and the region between CREBBP<\/jats:italic> and ADCY9<\/jats:italic> were risks to non\u2010syndromic cleft lip with or without cleft palate (NSCL\/P). However, the association of single nucleotide polymorphisms (SNPs) in these genes with NSCL\/P in Western China is unknown.<\/jats:p><\/jats:sec>Subjects and Methods<\/jats:title>We selected seven SNPs in NTN1<\/jats:italic>, NOG<\/jats:italic> and between CREBBP<\/jats:italic> and ADCY9<\/jats:italic>, and then performed transmission disequilibrium test (TDT), parent\u2010of\u2010origin effect and sliding window haplotype analysis to test the associations among 302 NSCL\/P case\u2013parent trios from Western Han Chinese.<\/jats:p><\/jats:sec>Results<\/jats:title>We found allele G at rs4791774 in NTN1<\/jats:italic> was significantly overtransmitted among non\u2010syndromic cleft lip only (NSCLO) (p<\/jats:italic>\u00a0=\u00a00.0067, OR\u00a0=\u00a01.79, 95% CI: 1.17\u20132.74); rs4791774 and rs9915089 tightly linked with each other among NSCL\/P (D<\/jats:italic>\u2032\u00a0=\u00a00.87, r<\/jats:italic>2<\/jats:sup>\u00a0=\u00a00.67) and haplotypes carrying the risk allele G at rs4791774 were always found to be overtransmitted from parents to cases. Motif analysis indicated that allele G at rs4791774 could greatly alter the affinity of Myc_disc7, so allele G at rs4791774 in NTN1<\/jats:italic> might modulate C\u2010MYC<\/jats:italic> transcription to participate in the aetiology of NSCLO.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Our study suggested allele G at rs4791774 in NTN1<\/jats:italic> gene is risk of NSCLO, which could greatly increase the risk to have a baby with cleft.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13009","type":"journal-article","created":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T12:34:21Z","timestamp":1543667661000},"page":"535-542","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["NTN1<\/i> gene was risk to non\u2010syndromic cleft lip only among Han Chinese population"],"prefix":"10.1111","volume":"25","author":[{"given":"ShuYuan","family":"Jiang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of cleft lip and palate, West China Hospital of Stomatology Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia\u2010Yu","family":"Shi","sequence":"additional","affiliation":[{"name":"Division of Growth and Development and Section of Orthodontics, School of Dentistry University of California Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan\u2010Song","family":"Lin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of cleft lip and palate, West China Hospital of Stomatology Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi\u2010Jun","family":"Duan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of cleft lip and palate, West China Hospital of Stomatology Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xieli","family":"Chen","sequence":"additional","affiliation":[{"name":"Beijing Smile Angel Children\u2019s Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian\u2010Jun","family":"Jiao","sequence":"additional","affiliation":[{"name":"HanDan Central Hospital Handan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Shen","sequence":"additional","affiliation":[{"name":"Beijing Smile Angel Children\u2019s Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoju","family":"Jin","sequence":"additional","affiliation":[{"name":"Beijing Smile Angel Children\u2019s Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao","family":"You","sequence":"additional","affiliation":[{"name":"Beijing Smile Angel Children\u2019s Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moyao","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Smile Angel Children\u2019s Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of cleft lip and palate, West China Hospital of Stomatology Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0129-0367","authenticated-orcid":false,"given":"Zhong\u2010Lin","family":"Jia","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of cleft lip and palate, West China Hospital of Stomatology Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2184.2008.00576.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.580"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.20595"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.333"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2933"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.24238"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/eos.12212"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.16.1.653"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.06.020"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1387\/ijdb.120117yk"},{"issue":"13","key":"e_1_2_8_12_1","first-page":"1862","article-title":"A 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