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AgP participants were submitted to periodontal treatment\u2014scaling and root planing plus antibiotics (SRP+A). Periodontal parameters, for example, probing depth (PD) and clinical attachment loss (CAL), were evaluated at baseline and at 1\u2010year. Serum IgG against Omp29 and serotypes <jats:italic>a<\/jats:italic>, <jats:italic>b<\/jats:italic>, and <jats:italic>c <\/jats:italic>were determined by ELISA. The levels of <jats:italic>A.\u00a0actinomycetemcomitans<\/jats:italic> JP2 clone were determined in subgingival biofilm samples by qPCR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Periodontal treatment resulted in significant reductions of PD, CAL, and IgG levels against Omp29, serotypes <jats:italic>b<\/jats:italic>, and <jats:italic>c<\/jats:italic>. After therapy, IgG levels against <jats:italic>A.\u00a0actinomycetemcomitans<\/jats:italic> serotypes, as well as the levels of the JP2 clone in AgP, became similar to controls. The reduction in JP2 clone count was correlated with a reduction of PD and IgG response against Omp29.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Scaling and root planing plus antibiotics decreased IgG levels response against Omp29 and <jats:italic>A.\u00a0actinomycetemcomitans<\/jats:italic> serotypes involved in the disease (<jats:italic>b<\/jats:italic> and <jats:italic>c<\/jats:italic>), while the serum response increased against tne commensal serotype (<jats:italic>a<\/jats:italic>), similar to what occurs in periodontally healthy individuals.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13010","type":"journal-article","created":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T12:48:35Z","timestamp":1543668515000},"page":"569-579","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Effect of periodontal treatment on <i>Aggregatibacter actinomycetemcomitans <\/i>colonization and serum IgG levels against <i>A.\u00a0actinomycetemcomitans <\/i>serotypes and Omp29 of aggressive periodontitis patients"],"prefix":"10.1111","volume":"25","author":[{"given":"Estela Sanches","family":"Rebeis","sequence":"first","affiliation":[{"name":"Division of Periodontics, Department of Stomatology, School of Dentistry University of Sao Paulo Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7307-0283","authenticated-orcid":false,"given":"Emmanuel","family":"Albuquerque\u2010Souza","sequence":"additional","affiliation":[{"name":"Division of Periodontics, Department of Stomatology, School of Dentistry University of Sao Paulo Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maike","family":"Paulino da Silva","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Institute of Biomedical Sciences University of S\u00e3o Paulo Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela","family":"Giudicissi","sequence":"additional","affiliation":[{"name":"Division of Periodontics, Department of Stomatology, School of Dentistry University of Sao Paulo Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcia P. 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