{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T06:10:37Z","timestamp":1778134237518,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,1,6]],"date-time":"2019-01-06T00:00:00Z","timestamp":1546732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","award":["7475"],"award-info":[{"award-number":["7475"]}],"id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Galectin\u20103, a member of beta\u2010galactoside\u2010binding proteins, can be found in cytoplasm and nucleus as well as extracellularly in various tissues and involved in many physiological and pathological processes. We aimed to measure the serum levels of galectin\u20103 in oral lichen planus (OLP) disease and compare the result with that observed in healthy ones.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In this cross\u2010sectional study, the serum levels of galectin\u20103 were measured in 56 healthy individuals and 53 pathologically proven OLP patients including those with atrophic\/erosive (33 cases) or reticular (20 cases) lesions, using enzyme\u2010linked immunosorbent assay (ELISA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with healthy individuals (1.1\u00a0\u00b1\u00a00.4\u00a0ng\/ml), galectin\u20103 serum levels in patients with OLP (3.1\u00a0\u00b1\u00a01.1\u00a0ng\/ml) were significantly elevated (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). Serum galectin\u20103 levels were elevated significantly in patients with atrophic\/erosive lesions compared to those of reticular (3.9\u00a0\u00b1\u00a02.1\u00a0ng\/ml vs. 1.9\u00a0\u00b1\u00a01.4\u00a0ng\/ml, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001), but it has not associated with age and gender.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The elevation of galectin\u20103 in OLP is a future tool to increase the knowledge about the possible etiology of the disease and may be helpful to differentiate atrophic\/erosive lesions from reticular ones. To the best of our knowledge, this is the first study evaluated the serum galectin\u20103 levels in OLP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13012","type":"journal-article","created":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T16:28:11Z","timestamp":1544113691000},"page":"466-470","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of the serum levels of galectin\u20103 in patients with oral lichen planus disease"],"prefix":"10.1111","volume":"25","author":[{"given":"Janan","family":"Ghapanchi","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Medicine, School of Dentistry Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azadeh","family":"Andisheh\u2010Tadbir","sequence":"additional","affiliation":[{"name":"Oral and Dental Disease Research Center, School of Dentistry Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pooriya","family":"Torkaman","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Medicine, School of Dentistry Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahyar","family":"Malekzadeh","sequence":"additional","affiliation":[{"name":"Shiraz Institute for Cancer Research, School of Medicine Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0479-7291","authenticated-orcid":false,"given":"Maryam","family":"Mardani","sequence":"additional","affiliation":[{"name":"Oral and Dental Disease Research Center, School of Dentistry Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,6]]},"reference":[{"issue":"3","key":"e_1_2_8_2_1","first-page":"EC06","article-title":"Sensitivity and specificity of galectin\u20103 and glypican\u20103 in follicular\u2010patterned and other thyroid neoplasms","volume":"10","author":"Al\u2010Sharaky D. 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