{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:06:24Z","timestamp":1787846784099,"version":"build-2784847793"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,1,6]],"date-time":"2019-01-06T00:00:00Z","timestamp":1546732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009624","name":"Yonsei University College of Dentistry","doi-asserted-by":"publisher","award":["2017-0012"],"award-info":[{"award-number":["2017-0012"]}],"id":[{"id":"10.13039\/501100009624","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the effect of local injection of receptor activator of nuclear factor kappa B ligand (RANKL) on experimental tooth movement and subsequent alveolar bone remodelling in mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Sixty mice were randomised to receive daily local RANKL or phosphate\u2010buffered saline injections in the buccal premaxillary bone for 14 of 21\u00a0days of incisor movement, followed by a 21\u2010day retention period. Five mice from each group were euthanised on days 0, 3, 7, 14, 21 and 42, and specimens were prepared for haematoxylin and eosin, tartrate\u2010resistant acid phosphatase and immunohistochemical staining. Five mice from each group were subjected to serial microcomputed tomography until day 42 for tooth movement and bone volume quantification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The experimental group showed significantly greater tooth movement and bone volume reduction on days 14 and 21; an increased osteoclast number on days 3, 7, 14 and 21; and no difference on day 42. Higher RANKL expression was observed on days 7 and 14, with remarkable alkaline phosphatase activity. No significant systemic changes were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Local RANKL injection leads to increased osteoclastic activity and facilitates tooth movement, followed by subsequent alveolar bone formation; this implies a reversible transitional acceleration of bone resorption.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13013","type":"journal-article","created":{"date-parts":[[2018,12,7]],"date-time":"2018-12-07T16:48:54Z","timestamp":1544201334000},"page":"550-560","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Local injection of RANKL facilitates tooth movement and alveolar bone remodelling"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1345-1973","authenticated-orcid":false,"given":"Chengri","family":"Li","sequence":"first","affiliation":[{"name":"Department of Orthodontics, Institute of Craniofacial Deformity, College of Dentistry Yonsei University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9399-7193","authenticated-orcid":false,"given":"Chooryung J.","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Gangnam Severance Dental Hospital, Institute of Craniofacial Deformity, College of Dentistry Yonsei University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung\u2010Ju","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Institute of Craniofacial Deformity, College of Dentistry Yonsei University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0782-3128","authenticated-orcid":false,"given":"Kee\u2010Joon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Institute of Craniofacial Deformity, College of Dentistry Yonsei University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.141"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2008.03.018"},{"issue":"1","key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1242\/jcs.03310","article-title":"Hyaluronan inhibits osteoclast differentiation via Toll\u2010like receptor 4","volume":"120","author":"Chang E. 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