{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:33:02Z","timestamp":1783384382697,"version":"3.54.6"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T00:00:00Z","timestamp":1548201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study was aimed to overview the treatment protocols of lip cancer and find out a cutoff point of tumor diameter and depth of invasion (DOI) for the survival parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>One hundred and ninety\u2010one patients with lip SCC were studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The average age of the patients was 62\u00a0years. Among 191 patients, 82.7% of the patients were men, 96.4% of them had lower lip cancer, and 84% were staged as early (pT<jats:sub>1,<\/jats:sub> pT<jats:sub>2<\/jats:sub>). Primary tumor excision with neck dissection was applied to 62.3% of the patients. Lymph node metastases rate was found to be 11%, and recurrence rate was 6.3%. There was statistically significant difference in between the tumor diameters and DOI values of patients with and without metastasis, and recurrence (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05, respectively). Regarding to the lymph node metastasis, the optimal cutoff point was found to be 7.5\u00a0mm for DOI and 21.5\u00a0mm for tumor diameter. Regarding to the recurrence, the optimal cutoff point was found to be 7.5\u00a0mm for DOI and 24.5\u00a0mm for tumor diameter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>T<jats:sub>2<\/jats:sub> lip cancer patients also seem to be in at\u2010risk group for metastasis and recurrence. As a conclusion, elective neck dissection and frequent follow\u2010up are recommended for these early\u2010stage lip cancer patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13017","type":"journal-article","created":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T14:14:07Z","timestamp":1544710447000},"page":"742-749","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Lip cancer: Reconsidering the at\u2010risk patients with pathological assessment"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9469-1468","authenticated-orcid":false,"given":"Ayca","family":"Ant","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Ankara A.Y. 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