{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T07:38:07Z","timestamp":1785224287417,"version":"3.55.0"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T00:00:00Z","timestamp":1546905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Biocosmetics"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the effects of Xerostom<jats:sup>\u00ae<\/jats:sup> toothpaste and mouthwash in primary Sj\u00f6gren's syndrome (pSS) patients with xerostomia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>A double\u2010blinded, randomized study where patients were assigned at baseline test or control products. Patients used the products 3\u00a0times\/day\/28\u00a0days. We used a visual analogue scale (VAS) for xerostomia and an Oral Health Impact Profile\u201014 (OHIP\u201014), baseline and after treatment, to assess possible improvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 28 patients with pSS were included in this study, but only 24 finished it (all women, mean age 55.21\u00a0\u00b1\u00a011.87), and 13 patients received the test and 11 the control. VAS and OHIP\u201014 scores decreased in both groups after treatment but significant differences between groups were not found. We do not detect VAS intragroup significant differences before and after treatment in test and control groups. A significant improvement in OHIP\u201014 was identified in the treatment group, while no significant differences were observed in the control group. No adverse effects were present.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Xerostom<jats:sup>\u00ae<\/jats:sup> toothpaste and mouthrinse may alleviate and improve quality of life without associated side effects, but further research with a larger number of participants and follow\u2010up are necessary to establish the positive efficacy of these topical products in pSS patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13019","type":"journal-article","created":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T13:10:50Z","timestamp":1545052250000},"page":"772-780","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effects of Xerostom<sup>\u00ae<\/sup> products on xerostomia in primary Sj\u00f6gren\u2019s syndrome: A randomized clinical trial"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5727-0920","authenticated-orcid":false,"given":"Rosa Mar\u00eda","family":"L\u00f3pez\u2010Pintor","sequence":"first","affiliation":[{"name":"Department of Dental Clinical Specialties, School of Dentistry Complutense University Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda","family":"Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Department of Dental Clinical Specialties, School of Dentistry Complutense University Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Serrano","sequence":"additional","affiliation":[{"name":"Department of Dental Clinical Specialties, School of Dentistry Complutense University Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7873-8000","authenticated-orcid":false,"given":"Miguel","family":"de Pedro","sequence":"additional","affiliation":[{"name":"Department of Dental Clinical Specialties, School of Dentistry Complutense University Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Fern\u00e1ndez\u2010Castro","sequence":"additional","affiliation":[{"name":"Rheumatology Service Hospital Infanta Sof\u00eda Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Casa\u00f1as","sequence":"additional","affiliation":[{"name":"Department of Dental Clinical Specialties, School of Dentistry Complutense University Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Dental Clinical Specialties, School of Dentistry Complutense University Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2012.01930.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12952"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-007-0159-3"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40093"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16442"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2014.06.015"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/adj.12023"},{"key":"e_1_2_8_9_1","article-title":"Oral health\u2010related quality of life in primary Sj\u00f6gren\u2019s syndrome","author":"Fern\u00e1ndez\u2010Mart\u00ednez G.","year":"2018","journal-title":"Reumatolog\u00eda Cl\u00ednica"},{"key":"e_1_2_8_10_1","first-page":"179","article-title":"One year in review 2017: Primary Sj\u00f6gren\u2019s syndrome","volume":"35","author":"Ferro F.","year":"2017","journal-title":"Clinical and Experimental Rheumatology"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-017-3898-9"},{"issue":"12","key":"e_1_2_8_12_1","first-page":"CD008934","article-title":"Interventions for the management of dry mouth: Topical therapies","volume":"7","author":"Furness S.","year":"2011","journal-title":"Cochrane Database Systematic Review"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev227"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2018.05.007"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12663-015-0752-y"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016359850136058"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2011.01088.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpor.2016.09.008"},{"key":"e_1_2_8_19_1","first-page":"161","article-title":"Xerostomia post\u2010radiation therapy. 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