{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:07:57Z","timestamp":1785798477197,"version":"3.56.0"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T00:00:00Z","timestamp":1546905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81830031"],"award-info":[{"award-number":["81830031"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570959"],"award-info":[{"award-number":["81570959"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007289","name":"Nanjing Medical University","doi-asserted-by":"publisher","award":["JX116GSP20171416"],"award-info":[{"award-number":["JX116GSP20171416"]}],"id":[{"id":"10.13039\/501100007289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010023","name":"Natural Science Research of Jiangsu Higher Education Institutions of China","doi-asserted-by":"publisher","award":["PAPD-2018-87"],"award-info":[{"award-number":["PAPD-2018-87"]}],"id":[{"id":"10.13039\/501100010023","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BL2014073"],"award-info":[{"award-number":["BL2014073"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["15KJA320002"],"award-info":[{"award-number":["15KJA320002"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Non\u2010syndromic tooth agenesis (NSTA) may share common genetic factors with non\u2010syndromic cleft lip with or without cleft palate (NSCL\/P). Single\u2010nucleotide polymorphisms (SNPs) were associated with individual's susceptibility to these anomalies. We selected five NSCL\/P\u2010associated SNPs from our previous genome\u2010wide association study (GWAS) to test for the associations with NSTA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>A total of 677 NSTA cases and 1,144 healthy controls were recruited in this case\u2013control study. Five genome\u2010wide NSCL\/P\u2010associated SNPs (rs2235371, rs7078160, rs8049367, rs4791774, and rs13041247) were genotyped by TaqMan platform and evaluated for the associations with NSTA using <jats:sc>plink<\/jats:sc> software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant associations between these SNPs and risk of NSTA were observed in the overall analysis and subgroup analysis with the number of missing teeth. However, in the subgroup analysis by tooth position, rs8049367 was nominally associated with mandibular premolar agenesis (Dominant model: OR<jats:sub>dom<\/jats:sub>\u00a0=\u00a00.66, 95% CI<jats:sub>dom<\/jats:sub>\u00a0=\u00a00.47\u20130.93, <jats:italic>p<\/jats:italic><jats:sub>dom<\/jats:sub>\u00a0=\u00a00.016; Heterozygote model: OR<jats:sub>het<\/jats:sub>\u00a0=\u00a00.60, 95% CI<jats:sub>het<\/jats:sub>\u00a0=\u00a00.41\u20130.88, <jats:italic>P<\/jats:italic><jats:sub>het<\/jats:sub>\u00a0=\u00a00.008). Rs4791774 showed a nominal association with congenitally missing maxillary canine (Dominant model: OR<jats:sub>dom<\/jats:sub>\u00a0=\u00a00.53, 95% CI<jats:sub>dom<\/jats:sub>\u00a0=\u00a00.28\u20130.98, <jats:italic>p<\/jats:italic><jats:sub>dom<\/jats:sub>\u00a0=\u00a00.041; Heterozygote model: OR<jats:sub>het<\/jats:sub>\u00a0=\u00a00.50<jats:italic>, <\/jats:italic>95% CI<jats:sub>het<\/jats:sub><jats:italic>\u00a0=\u00a0<\/jats:italic>0.26\u20130.97, <jats:italic>P<\/jats:italic><jats:sub>het<\/jats:sub>\u00a0=\u00a00.041) and premolar (Additive model: OR\u00a0=\u00a00.59, 95% CI\u00a0=\u00a00.36\u20130.96, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.035).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study showed that NSCL\/P susceptible loci rs8049367 and rs4791774 were probably associated with the risk of NSTA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13024","type":"journal-article","created":{"date-parts":[[2018,12,22]],"date-time":"2018-12-22T05:34:31Z","timestamp":1545456871000},"page":"803-811","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Non\u2010syndromic cleft lip with or without palate susceptible loci is associated with tooth agenesis"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8157-0800","authenticated-orcid":false,"given":"Liwen","family":"Fan","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University Nanjing China"},{"name":"Department of Orthodontics, Affiliated Hospital of Stomatology Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyi","family":"Kan","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University Nanjing China"},{"name":"Department of Orthodontics, Affiliated Hospital of Stomatology Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University Nanjing China"},{"name":"Department of Orthodontics, Affiliated Hospital of Stomatology Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Xu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Li","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University Nanjing China"},{"name":"Department of Orthodontics, Affiliated Hospital of Stomatology Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guirong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University Nanjing China"},{"name":"Department of Orthodontics, Affiliated Hospital of Stomatology Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Ma","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University Nanjing China"},{"name":"Department of Orthodontics, Affiliated Hospital of Stomatology Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Lou","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University Nanjing China"},{"name":"Department of Orthodontics, Affiliated Hospital of Stomatology Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Li","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University Nanjing China"},{"name":"Department of Orthodontics, Affiliated Hospital of Stomatology Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University Nanjing China"},{"name":"Department of Orthodontics, Affiliated Hospital of Stomatology Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University Nanjing China"},{"name":"Department of Orthodontics, Affiliated Hospital of Stomatology Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongchu","family":"Pan","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University Nanjing China"},{"name":"Department of Orthodontics, Affiliated Hospital of Stomatology Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12881-015-0154-5"},{"issue":"4","key":"e_1_2_8_3_1","first-page":"E18","article-title":"HATS syndrome: Hemimaxillary enlargement, asymmetry of the face, tooth abnormalities, and skin findings","volume":"94","author":"Alshaiji J. M.","year":"2014","journal-title":"Cutis"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1090"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp427"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.10011"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1987.tb00524.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13072-018-0197-x"},{"issue":"12","key":"e_1_2_8_9_1","first-page":"2188","article-title":"Association of BMP4 polymorphisms with isolated tooth agenesis in a Chinese Han population: A case\u2010control study","volume":"19","author":"Gong M.","year":"2015","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/eos.12414"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000006724"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2016.07.009"},{"issue":"5","key":"e_1_2_8_13_1","first-page":"515","article-title":"Rare and common variants conferring risk of tooth","volume":"97","author":"Jonsson L.","year":"2018","journal-title":"Agenesis."},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a008425"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31382"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31381"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910708601013"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2012.00965.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034517726284"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_2003_040_0172_daotpl_2.0.co_2"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0158273"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2360"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514527617"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02788"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36520"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2010.01.031"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.1330210413"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M601543200"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2004.09.011"},{"issue":"7","key":"e_1_2_8_30_1","first-page":"S11","article-title":"Global birth prevalence of orofacial clefts: A systematic review","volume":"98","author":"Panamonta V.","year":"2015","journal-title":"Journal of the Medical Association of Thailand"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/eos.12141"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.17.2735"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-016-1733-z"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.4103\/1735-3327.150286"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/5.2.145"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.1.13"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0494-348"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.2319\/020513-104.1"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-013-1360-x"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7414"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1597\/15-186"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2016.121"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034517743930"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21368-z"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes9050255"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515583999"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fodi.13024","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.13024","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/odi.13024","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.13024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T01:59:18Z","timestamp":1694397558000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.13024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,8]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1111\/odi.13024"],"URL":"https:\/\/doi.org\/10.1111\/odi.13024","archive":["Portico"],"relation":{},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,8]]},"assertion":[{"value":"2018-07-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}