{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T04:56:41Z","timestamp":1772513801097,"version":"3.50.1"},"reference-count":58,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T00:00:00Z","timestamp":1548806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Extrinsic and intrinsic pathways of apoptosis are involved in generalized aggressive periodontitis (GAgP). The aim of this study was to evaluate 6\u2010month clinical outcomes relative to apoptosis of one\u2010stage full\u2010mouth disinfection (OSFMD) and systemic antibiotics (SA) in the treatment of GAgP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010six patients with GAgP were included in this prospective follow\u2010up intervention study. Gingival crevicular fluid (GCF) was collected from patients at baseline and 3 and 6\u00a0months after periodontal therapy, which consisted of OSFMD and SA (amoxicillin and metronidazole, 500\u00a0mg each for 7\u00a0days). The levels of p53, caspase\u20103, TNF\u2010\u03b1, TRAIL, IL\u20101\u03b2, and IL\u201010 in GCF were measured via ELISA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Periodontal parameters were improved at 3 and 6\u00a0months compared to baseline (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). p53 was decreased up to 6\u00a0months (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). TRAIL, TNF\u2010\u03b1, and IL\u201010 were similar at baseline and 3 and 6\u00a0months. Caspase\u20103 and IL\u20101\u03b2 were decreased at 3\u00a0months (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05), but similar at 6\u00a0months compared to baseline (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although OSFMD plus SA improves clinical periodontal parameters up to 6\u00a0months, this treatment protocol differentially regulates the apoptosis markers caspase\u20103 at 3\u00a0months and p53 at 6\u00a0months without influencing TRAIL in GCF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13032","type":"journal-article","created":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T13:52:42Z","timestamp":1546955562000},"page":"839-847","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Six\u2010month clinical outcomes of non\u2010surgical periodontal treatment with antibiotics on apoptosis markers in aggressive periodontitis"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4798-4548","authenticated-orcid":false,"given":"K\u00fcbra","family":"Aral","sequence":"first","affiliation":[{"name":"Division of Periodontics Malatya Oral and Dental Heath Hospital Malatya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00fcneyt A.","family":"Aral","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry, Inonu University  Malatya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvonne","family":"Kapila","sequence":"additional","affiliation":[{"name":"Department of Orofacial Sciences, School of Dentistry University of California  California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.130095"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100468"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01795.x"},{"key":"e_1_2_9_5_1","first-page":"229","article-title":"Problems and proposals for recording gingivitis and plaque","volume":"25","author":"Ainamo","year":"1975","journal-title":"International Dental Journal"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12223"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011714"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M307638200"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20067"},{"key":"e_1_2_9_10_1","first-page":"986","article-title":"Gingival crevicular fluid and salivary periostin levels in non\u2010smoker subjects with chronic and aggressive periodontitis: Periostin levels in chronic and aggressive periodontitis","volume":"39","author":"Aral C. A.","year":"2016","journal-title":"Inflammation"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0716"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2010.00353.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0285.2010.00950.x"},{"key":"e_1_2_9_15_1","first-page":"706","article-title":"New knowledge of the pathogenesis of periodontal disease","volume":"35","author":"Bascones A.","year":"2004","journal-title":"Quintessence International"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02364.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110513"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2010.01278.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.150632"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01817.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.070465"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.3.374"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2009.00334.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2001.028003233.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.090732"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207116"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12230"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2011.96"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.4.517"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510376402"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2003.02012.x"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00814.x"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.12.2276"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2005.04966.x"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2017.170244"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2014.02.007"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2004.03678.x"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2010.10.007"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1967.38.6.610"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509350708"},{"key":"e_1_2_9_41_1","first-page":"811","article-title":"The use of 2 antibiotic regimens in aggressive periodontitis: Comparison of changes in clinical parameters and gingival crevicular fluid biomarkers","volume":"39","author":"Machtei E. E.","year":"2008","journal-title":"Quintessence International"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1995.tb08340.x"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2006.00204.x"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.6.632"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/039463200902200111"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2001.280108.x"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2011.01348.x"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1177\/039463200702000211"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345950740080501"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.6.646"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-017-2192-1"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.100579"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.10.7337"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356408993968"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12574"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080347"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2952"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1097-141"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2017.160806"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fodi.13032","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.13032","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/odi.13032","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.13032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T01:58:01Z","timestamp":1694397481000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.13032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,30]]},"references-count":58,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1111\/odi.13032"],"URL":"https:\/\/doi.org\/10.1111\/odi.13032","archive":["Portico"],"relation":{},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,30]]},"assertion":[{"value":"2018-09-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}