{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T20:22:04Z","timestamp":1781209324811,"version":"3.54.1"},"reference-count":52,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T00:00:00Z","timestamp":1550534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003810","name":"Hospital de Cl\u00ednicas de Porto Alegre","doi-asserted-by":"publisher","award":["14\u20100329"],"award-info":[{"award-number":["14\u20100329"]}],"id":[{"id":"10.13039\/501100003810","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Our objective was to evaluate the Transcranial direct current stimulation (tDCS) effect on facial allodynia induced by chronic constriction of the infraorbital nerve (CCI\u2010ION) and on the brainstem levels of TNF\u2010\u03b1, NGF, IL\u201010, and serum LDH in rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Rats were exposed to the CCI\u2010ION model. Facial allodynia was assessed by von Frey filaments test at baseline, 3, 7, 10, and 14\u00a0days postsurgery and 24\u00a0hr and 7\u00a0days after the bimodal tDCS sessions for 20\u00a0min\/day\/8\u00a0days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Chronic constriction of the infraorbital nerve induced a significant decrease in the mechanical threshold 14\u00a0days after surgery. This effect was reversed by tDCS treatment, with the mechanical threshold returning to basal levels at 24\u00a0hr after the end of the treatment and it persisted for 7\u00a0days after the end of the treatment. tDCS also decreased LDH serum levels compared to those in the control group. There was an interaction between pain and treatment with respect to brainstem levels of NGF, TNF\u2010\u03b1, and IL\u201010.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Chronic constriction of the infraorbital nerve model was effective in establishing trigeminal neuropathic pain on 14\u00a0days after surgery, and tDCS reduced allodynia and LDH serum levels and promoted alterations in NGF, TNF\u2010\u03b1, and IL\u201010 brainstem levels. Thus, we suggest that tDCS may be a potential therapy in the trigeminal pain treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13038","type":"journal-article","created":{"date-parts":[[2019,1,12]],"date-time":"2019-01-12T16:49:11Z","timestamp":1547311751000},"page":"888-897","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Transcranial direct current stimulation (tDCS) and trigeminal pain: A preclinical study"],"prefix":"10.1111","volume":"25","author":[{"given":"Etiane Micheli Meyer","family":"Callai","sequence":"first","affiliation":[{"name":"Pharmacology of Pain and Neuromodulation Laboratory: Preclinical Researches, Department of Pharmacology, Institute of Basic Health Sciences (ICBS) Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre Brazil"},{"name":"Animal Experimentation Unit and Graduate Research Group Hospital de Cl\u00ednicas de Porto Alegre Porto Alegre Brazil"},{"name":"Graduate Program 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