{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T14:27:22Z","timestamp":1770906442505,"version":"3.50.1"},"reference-count":80,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T00:00:00Z","timestamp":1559088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007190","name":"Unilever","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To conduct a systematic review of studies exploring potential biomarkers for development, course, and efficacy of treatment of lymphomas in salivary glands of patients with Sj\u00f6gren's syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Eligible studies were identified through a comprehensive search of two databases, that is, PubMed and EMBASE. Quality of included articles was assessed with the \u201cQuality In Prognosis Studies\u201d (QUIPS) tool. The \u201cCHecklist for critical Appraisal and data extraction for systematic Reviews of prediction Modelling Studies\u201d (CHARMS) was used to facilitate data extraction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010eight studies met the inclusion criteria. Only one study assessed the progression of lymphoma. Moderate risk of bias was detected in \u201coutcome measurement,\u201d \u201cstudy participation,\u201d and \u201cstudy confounding\u201d domains. Parotid gland enlargement, mixed monoclonal cryoglobulins, and low C4 levels represented strongest predictors of lymphoma development. The role of histological biomarkers, and specifically germinal centers, remains controversial. Clinical and methodological heterogeneity across studies precluded conduct of a meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Specific biomarkers in combination with clinical manifestations represent potential candidates for advancing precision medicine approaches to lymphoma prediction in patients with Sj\u00f6gren's syndrome. Current focus has increasingly been on genetic and epigenetic markers as candidate predictors. Predictive accuracy of key biomarker candidates remains to be tested in well\u2010designed prospectively followed Sj\u00f6gren's syndrome cohorts.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13041","type":"journal-article","created":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T10:39:31Z","timestamp":1548067171000},"page":"49-63","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["World Workshop on Oral Medicine VII: Biomarkers predicting lymphoma in the salivary glands of patients with Sj\u00f6gren\u2019s syndrome\u2014A systematic review"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3115-3977","authenticated-orcid":false,"given":"Konstantina","family":"Delli","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, University Medical Center Groningen University of Groningen Groningen The 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