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Groups of rats received 0, 8, 20, 50 or 125\u00a0\u00b5g\/kg IV ZOL\/4\u00a0weeks encompassing osteoporosis and oncology ZOL doses. Rats from each dose group (<jats:italic>n<\/jats:italic>\u00a0=\u00a09\u201316) were necropsied after 12, 18, 24 and 30\u00a0weeks of treatment. BRONJ\u2010like lesion prevalence and tissue\u2010level features were assessed grossly, histopathologically and by MicroCT. ZOL bone turnover effects were assessed by femoral peripheral quantitative computed tomography, serum bone turnover marker ELISAs and osteoclast immunolabelling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Prevalence of BRONJ\u2010like lesions was significantly associated with (a) ZOL treatment duration, but plateaued at the lowest oncologic dose, and (b) there was a similar dose\u2010related plateau in the systemic anti\u2010resorptive effect of ZOL. ZOL and BRONJ\u2010like lesions also altered the structural and tissue\u2010level features of the jaw.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The relationship between BRONJ\u2010like lesion prevalence and ZOL dose and duration varies depending on the co\u2010 or pre\u2010existing oral risk factor. At clinically relevant doses of ZOL, BRONJ\u2010like lesions are associated with anti\u2010resorptive activity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13052","type":"journal-article","created":{"date-parts":[[2019,2,3]],"date-time":"2019-02-03T11:48:51Z","timestamp":1549194531000},"page":"1116-1135","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Zoledronate treatment duration is linked to bisphosphonate\u2010related osteonecrosis of the jaw prevalence in rice rats with generalized periodontitis"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2261-3380","authenticated-orcid":false,"given":"Jonathan G.","family":"Messer","sequence":"first","affiliation":[{"name":"Department of Physiological Sciences University of Florida Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica M.","family":"Jiron","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences University of Florida Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge L.","family":"Mendieta Calle","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences University of Florida Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn J.","family":"Castillo","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences University of Florida Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronnie","family":"Israel","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences University of Florida Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ean G.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Research Service VA Medical Center Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua F.","family":"Yarrow","sequence":"additional","affiliation":[{"name":"Research Service VA Medical Center Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Van Poznak","sequence":"additional","affiliation":[{"name":"University of Michigan Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmyya","family":"Kesavalu","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Biology College of Dentistry Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald B.","family":"Kimmel","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences University of Florida Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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