{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T18:41:08Z","timestamp":1780512068014,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T00:00:00Z","timestamp":1553644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008549","name":"Shanxi Medical University","doi-asserted-by":"publisher","award":["14055245"],"award-info":[{"award-number":["14055245"]}],"id":[{"id":"10.13039\/501100008549","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Oral lichen planus (OLP) is a chronic inflammatory condition with an unclear pathological mechanism. I\u03baB kinase \u03b1 (IKK\u03b1)\u2010regulated mammary serine protease inhibitor (MASPIN) has been shown to mediate inflammation, particularly in cancers. Here, we explored the expression of MASPIN in OLP and its role in the inflammatory response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Immunohistochemistry staining and reverse transcription\u2010polymerase chain reaction assays were used to detect the subcellular localization and expression of MASPIN and IKK\u03b1 in OLP and healthy control tissues. Levels of the inflammatory factors were compared with enzyme\u2010linked immunosorbent assays. MASPIN and IKK\u03b1 were overexpressed and silenced, respectively, in an inflammation model of human oral keratinocytes (HOKs) stimulated with lipopolysaccharide (LPS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mammary serine protease inhibitor expression was down\u2010regulated, whereas IKK\u03b1 expression was up\u2010regulated in OLP tissues (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01). The levels of tumour necrosis factor\u2010alpha and interleukin\u20106 in OLP tissues were increased compared to those of healthy controls (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01). MASPIN overexpression in LPS\u2010stimulated HOK cells inhibited the levels of IKK\u03b1 and the secretion of inflammatory cytokines. By contrast, IKK\u03b1 silencing promoted the expression of MASPIN and inhibited the secretion of inflammatory cytokines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both MASPIN and IKK\u03b1 are involved in the inflammatory process of OLP, suggesting potential therapeutic targets.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13054","type":"journal-article","created":{"date-parts":[[2019,2,9]],"date-time":"2019-02-09T10:45:04Z","timestamp":1549709104000},"page":"1091-1099","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Role of mammary serine protease inhibitor on the inflammatory response in oral lichen planus"],"prefix":"10.1111","volume":"25","author":[{"given":"Na","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Oral Medicine Shanxi Medical University School and Hospital of Stomatology Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoyin","family":"Li","sequence":"additional","affiliation":[{"name":"Jilin University School and Hospital of Stomatology Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuanzhuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Shanxi Medical University School and Hospital of Stomatology Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Shanxi Medical University School and Hospital of Stomatology Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Shanxi Medical University School and Hospital of Stomatology Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Shanxi Medical University School and Hospital of Stomatology Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Shanxi Medical University School and Hospital of Stomatology Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiyan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Shanxi Medical University School and Hospital of Stomatology Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6527-1165","authenticated-orcid":false,"given":"Fang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Shanxi Medical University School and Hospital of Stomatology Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.03.029"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coms.2012.11.007"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20782"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/2001-1326-2-8"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"56309","DOI":"10.18632\/oncotarget.10462","article-title":"Nuclear IKKalpha mediates microRNA\u20107\/\u2010103\/107\/21 inductions to downregulate maspin expression in response to HBx overexpression","volume":"7","author":"Chen W. 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H.","year":"2017","journal-title":"Journal of Oral Science Research"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2016.12.021"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2016.04.010"},{"key":"e_1_2_8_29_1","first-page":"1555","article-title":"Expression of urokinase\u2010type plasminogen activator\/urokinase\u2010type plasminogen activator receptor and maspin in oral squamous cell carcinoma: Association with mode of invasion and clinicopathological factors","volume":"26","author":"Yoshizawa K.","year":"2011","journal-title":"Oncology Reports"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12655"},{"key":"e_1_2_8_31_1","first-page":"48","article-title":"Preliminary study on Aspergillus fumigatus\u2010induced IKKalpha controlled maspin protein expression in respiratory epithelial cells of rats","volume":"48","author":"Zhang F.","year":"2013","journal-title":"Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8290962"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fodi.13054","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.13054","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/odi.13054","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.13054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T04:54:40Z","timestamp":1694148880000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.13054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,27]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1111\/odi.13054"],"URL":"https:\/\/doi.org\/10.1111\/odi.13054","archive":["Portico"],"relation":{},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,27]]},"assertion":[{"value":"2018-11-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}