{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:23:44Z","timestamp":1787775824243,"version":"build-2784847793"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,3,3]],"date-time":"2019-03-03T00:00:00Z","timestamp":1551571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this randomized split\u2010mouth clinical trial was to evaluate the effects of ozone therapy on clinical and biochemical parameters of moderate to severe generalized periodontitis patients after non\u2010surgical periodontal therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 36 moderate to severe generalized periodontitis patients were included in the study. The patients were systemically healthy and 18 to 64\u00a0years of age. Periodontal parameters, including plaque index (PI), gingival index (GI), probing depth (PD), percentage of bleeding on probing, percentage of pockets deeper than 5\u00a0mm and clinical attachment level (CAL), and percentage of \u22653\u00a0mm CAL, were evaluated at baseline and 3\u00a0months following periodontal therapy. All participants were treated non\u2010surgically. Topical gaseous ozone was applied into periodontal pockets twice a week for 2\u00a0weeks during active periodontal therapy. Gingival crevicular fluid pentraxin\u20103 (PTX\u20103), interleukin\u20101\u03b2 (IL\u20101\u03b2), and high sensitivity C\u2010reactive protein (Hs\u2010CRP) were evaluated. All statistical data were analyzed using SPSS software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Total of 36 participants completed the study (18 males, 18 females). PI, GI, PD, percentage of bleeding on probing, percentage of pockets deeper than 5\u00a0mm and CAL, and percentage of \u22653\u00a0mm CAL were improved, and there were no significant differences between the two sides. All inflammatory parameters, PTX\u20103, Hs\u2010CRP, and IL\u20101, were reduced at 3\u2010month follow\u2010up. Only the decrease in PTX\u20103 levels between baseline and 3\u2010month follow\u2010up was statistically significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Ozone therapy did not have any additional effect on periodontal parameters. All cytokines were reduced after periodontal therapy. Only PTX\u20103 levels were significantly lower at ozone sites compared to those at the control sites.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.13060","type":"journal-article","created":{"date-parts":[[2019,2,10]],"date-time":"2019-02-10T04:44:42Z","timestamp":1549773882000},"page":"1195-1202","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["The effects of ozone therapy on periodontal therapy: A randomized placebo\u2010controlled clinical trial"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0359-2462","authenticated-orcid":false,"given":"Zekeriya","family":"Tasdemir","sequence":"first","affiliation":[{"name":"Faculty of Dentistry, Department of Periodontology Erciyes University Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merve N.","family":"Oskaybas","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Department of Periodontology Erciyes University Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arzu B.","family":"Alkan","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Department of Periodontology Bezm\u2010i Alem Vakif University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omer","family":"Cakmak","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Department of Periodontology Afyonkarahisar Health Sciences University Afyonkarahisar Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/1305-7456.184168"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-017-2163-6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12177"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.160009"},{"key":"e_1_2_9_6_1","first-page":"ZE21","article-title":"C\u2010reactive protein (CRP) and its association with periodontal disease: a brief review","volume":"8","author":"Bansal T.","year":"2014","journal-title":"Journal of Clinical and Diagnostic Research: JCDR"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110616"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12419"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.18-0157"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.4137\/CMC.S1062"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2015.00062"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10266-011-0042-1"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2009.05.006"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-124X.107472"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2004.04.003"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12451"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01585.x"},{"issue":"4","key":"e_1_2_9_18_1","first-page":"486","article-title":"Saliva and Serum Levels of Pentraxin\u20103 and Interleukin\u20101\u03b2 in Generalized Aggressive or Chronic Periodontitis","volume":"86","author":"G\u00fcm\u00fc\u015f P.","year":"2014","journal-title":"Journal of Periodontology."},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2041-1014.2012.00663.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-012-0711-7"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2003.02016.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/657025"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12557"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.4103\/njcp.njcp_82_17"},{"key":"e_1_2_9_25_1","first-page":"79","article-title":"Effect of ozonised water on chronic periodontitis\u2010a clinical study","volume":"5","author":"Katti S. 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