{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T19:56:22Z","timestamp":1775159782721,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,3,15]],"date-time":"2019-03-15T00:00:00Z","timestamp":1552608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To verify whether there are differences between populations of CD8\u00a0+\u00a0and FoxP3\u00a0+\u00a0T cells in lesions of oral lichen planus associated with hepatitis C virus chronic infection (OLP\u2010HCV) and lesions of idiopathic oral lichen planus (OLP\u2010I).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A case\u2013control study was performed using a convenience sample of 11 paraffin\u2010embedded tissue blocks of OLP\u2010HCV and 19 of OLP\u2010I. Histological sections stained with haematoxylin and eosin were used to classify the intensity of inflammatory infiltrate. Immunohistochemistry was used to identify CD8\u00a0+\u00a0and FoxP3\u00a0+\u00a0T cells. The count of positive cells was compared between the two groups and correlated to clinical and demographic data (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no statistically significant differences in the distribution of CD8\u00a0+\u00a0and FoxP3\u00a0+\u00a0T cells regarding the inflammatory infiltrate in lesions of OLP\u2010HCV and OLP\u2010I. Atrophic\/erosive lesions showed a higher relationship between counts of CD8\/FoxP3 T cells <jats:italic>per<\/jats:italic> mm<jats:sup>2<\/jats:sup> (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.018) and counts of CD8\u00a0+\u00a0T cells <jats:italic>per<\/jats:italic> mm<jats:sup>2<\/jats:sup> (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.034) in OLP\u2010HCV group compared to OLP\u2010I group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Overall, no difference was found between cell populations in the lesions of OLP\u2010HCV and OLP\u2010I. However, atrophic\/erosive lesions of OLP\u2010HCV had a higher amount of CD8\u00a0+\u00a0T cells and lower FoxP3 expression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13069","type":"journal-article","created":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T04:10:45Z","timestamp":1551154245000},"page":"1100-1106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Subset of CD8+ and FOXP3 + T cells in lichen planus associated with chronic hepatitis C infection"],"prefix":"10.1111","volume":"25","author":[{"given":"Alessandra Rodrigues","family":"de Camargo","sequence":"first","affiliation":[{"name":"Department of Stomatology Federal University of Santa Catarina Florianopolis Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6986-9148","authenticated-orcid":false,"given":"Jefferson Rocha","family":"Ten\u00f3rio","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Pathology, School of Dentistry University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana","family":"Martins","sequence":"additional","affiliation":[{"name":"School of Dentistry University of Santo Amaro S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliane Janete","family":"Grando","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Health Sciences Centre Federal University of Santa Catarina Florianopolis Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther Buzaglo Dantas","family":"Corr\u00eaa","sequence":"additional","affiliation":[{"name":"Department of Medical Clinics, Health Sciences Centre Federal University of Santa Catarina Florianopolis Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00edlia","family":"Trierveiler","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Pathology, School of Dentistry University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9573-2858","authenticated-orcid":false,"given":"Karem L.","family":"Ortega","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Pathology, School of Dentistry University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2000.8533"},{"key":"e_1_2_8_3_1","first-page":"1100","article-title":"From stability to dynamics: Understanding molecular mechanisms of regulatory T cells through Foxp3 transcriptional dynamics","volume":"4","author":"Bending D.","year":"2018","journal-title":"Clinical and Experimental Immunology"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13317-010-0005-5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-07-2598"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.07.035"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2014.10.005"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2005.00303.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1996.tb01726.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(02)00183-6"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy585"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.12.013"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.02.037"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2013.37"},{"issue":"12","key":"e_1_2_8_15_1","first-page":"2339","article-title":"Frequency of FOXP3+ regulatory T\u2010cells in the blood of chronic hepatitis c patients with immune mediated skin manifestations; 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