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Dysregulated expression of lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s is implicated in cancer initiation, progression and metastasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To explore, map and summarize the extent of evidence from clinical studies investigating the differential expression of lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s in oral\/tongue squamous cell carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PubMed, Scopus and Web of Science were used as search engines. Clinical, full\u2010length, English language studies were included. <jats:styled-content style=\"fixed-case\">PRISMA<\/jats:styled-content>\u2010ScR protocol was used to evaluate and present results. The present scoping review summarizes relationships of the differential expression of lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s with the presence of tumour and with clinicopathological features including survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Almost half of the investigated transcripts have been explored in more than one study, yet not always with consistent results. The collected data were also compared to the limited studies investigating oral epithelial dysplasia. Data are not easily comparable, first because of different methods used to define what differential expression is, and second because only a limited number of studies performed multivariate analyses to identify clinicopathological features associated with the differentially expressed lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Standard methods and more appropriate data analyses are needed in order to achieve reliable results from future studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13076","type":"journal-article","created":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T11:20:02Z","timestamp":1559128802000},"page":"88-101","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["World Workshop on Oral Medicine VII: Clinical evidence of differential expression of lncRNAs in oral squamous cell carcinoma: A scoping review"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3972-1203","authenticated-orcid":false,"given":"Monica","family":"Pentenero","sequence":"first","affiliation":[{"name":"Department of Oncology, Oral Medicine and Oral Oncology Unit University of Turin  Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leah M.","family":"Bowers","sequence":"additional","affiliation":[{"name":"Department of Stomatology Division of Oral Medicine Medical University of South Carolina  Charleston SC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruwan","family":"Jayasinghe","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Periodontology Faculty of Dental Sciences University of Peradeniya  Peradeniya Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tami","family":"Yap","sequence":"additional","affiliation":[{"name":"Melbourne Dental School University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sok Ching","family":"Cheong","sequence":"additional","affiliation":[{"name":"Head and Neck Cancer Research Team Cancer Research Malaysia  Subang Jaya Selangor Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2162-8572","authenticated-orcid":false,"given":"Alexander R.","family":"Kerr","sequence":"additional","affiliation":[{"name":"New York University College of Dentistry  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1642-6204","authenticated-orcid":false,"given":"Camile S.","family":"Farah","sequence":"additional","affiliation":[{"name":"Australian Centre for Oral Oncology Research &amp; 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