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Occurrence of SPC\u2010HE was monitored until December 31, 2014. Results were expressed as adjusted relative risk (aRR) and 95% confidence interval (CI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and fifty\u2010eight out of 4,494 subjects with oral cancer developed SPC\u2010HE (incidence rate: 6.47 per 1,000 person\u2010years). Relative to patients with primary cancers in the lip, the risk of an SPC\u2010HE was higher in patients with primary cancers in oropharynx (aRR: 19.98, 95% CI: 4.72\u201384.55), floor of mouth (aRR: 12.13, 95% CI: 2.67\u201355.15), and hard palate (aRR: 7.31, 95% CI: 1.65\u201332.37), but not in patients with cancers in tongue (aRR: 3.67, 95% CI: 0.89\u201315.17) or gum (aRR: 3.99, 95% CI: 0.92\u201317.35). Regression analyses also showed the risk of an SPC\u2010HE was greater in alcohol drinkers than those who did not (aRR: 1.65, 95% CI: 1.10\u20132.48).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Compared with the initial cancer in the lip, patients with a cancer in the oropharynx, floor of mouth, and hard palate had a higher risk for the SPC\u2010HE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13080","type":"journal-article","created":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T16:59:03Z","timestamp":1551459543000},"page":"1067-1075","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Risk for a second primary hypopharyngeal and esophageal cancer after an initial primary oral cancer"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1640-2920","authenticated-orcid":false,"given":"William Wang\u2010Yu","family":"Su","sequence":"first","affiliation":[{"name":"Division of Otorhinolaryngology\u2010 Head &amp; Neck Surgery Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation New Taipei City Taiwan"},{"name":"School of Medicine Tzu Chi University Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu\u2010Lin","family":"Chuang","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Preventive Medicine, College of Public Health National Taiwan University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0628-8768","authenticated-orcid":false,"given":"Amy Ming\u2010Fang","family":"Yen","sequence":"additional","affiliation":[{"name":"School of Oral Hygiene, College of Oral Medicine Taipei Medical University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9750-3015","authenticated-orcid":false,"given":"Sam Li\u2010Sheng","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Oral Hygiene, College of Oral Medicine Taipei Medical University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Ching\u2010Yuan","family":"Fann","sequence":"additional","affiliation":[{"name":"Department and Graduate Institute of Health Care Management Kainan University Tao\u2010Yuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherry Yueh\u2010Hsia","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Health Care Management and Healthy Aging Research Center Chang Gung University Tao\u2010Yuan Taiwan"},{"name":"Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han\u2010Mo","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine National Taiwan University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiu\u2010Wen","family":"Su","sequence":"additional","affiliation":[{"name":"Big Data Research Center Changhua Christian Hospital Changhua Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen\u2010Yang","family":"Hsu","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Preventive Medicine, College of Public Health National Taiwan University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mu\u2010Kuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010 Head &amp; 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