{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:26:03Z","timestamp":1777479963529,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T00:00:00Z","timestamp":1559088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the evidence for treatment of oral involvement of pemphigus and pemphigoid with biologics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>This systematic review used a comprehensive search strategy to identify literature describing oral involvement of pemphigus or pemphigoid treated with a biologic agent. The primary outcome measures were efficacy and safety of biologic therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Inclusion criteria were met by 154 studies including over 1200 patients. Treatment of pemphigus with a total of 11 unique biologic agents and 3 unique combinations of agents is reported. Five randomized controlled trials (RCT) were included in the final analysis that investigated infliximab, IVIg, rituximab, and autologous platelet\u2010rich plasma therapy for pemphigus vulgaris. Three non\u2010RCT studies reported on successful rituximab or IVIg therapy for mucous membrane pemphigoid. Studies demonstrated considerable heterogeneity in agent, methods, and quality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Evidence clearly describing oral tissue response to biologic therapy is sparse. Two RCTs support use of rituximab, one supports use of IVIg, and one pilot study suggests intralesional injection of autologous platelet\u2010rich plasma aids healing of oral PV lesions. As oral lesions of pemphigus and pemphigoid can be refractory to systemic therapy, drug trials including biologic therapies should document details regarding response of the oral lesions to therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13083","type":"journal-article","created":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T11:17:29Z","timestamp":1559128649000},"page":"111-121","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["World Workshop of Oral Medicine VII: A systematic review of immunobiologic therapy for oral manifestations of pemphigoid and pemphigus"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4472-9974","authenticated-orcid":false,"given":"Jacqueline W.","family":"Mays","sequence":"first","affiliation":[{"name":"Oral Immunobiology Unit National Institute of Dental and Craniofacial Research National Institutes of Health  Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6376-9867","authenticated-orcid":false,"given":"Barbara P.","family":"Carey","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Guy's and St Thomas\u2019 NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachael","family":"Posey","sequence":"additional","affiliation":[{"name":"William Rand Kenan, Jr. Library of Veterinary Medicine North Carolina State University  Raleigh North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4979-4318","authenticated-orcid":false,"given":"Luiz Alcino","family":"Gueiros","sequence":"additional","affiliation":[{"name":"Oral Medicine Unit Department of Clinic and Preventive Dentistry Universidade Federal de Pernambuco  Recife Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"France","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine University of Pennsylvania School of Dental Medicine  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Setterfield","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Guy's and St Thomas\u2019 NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sook Bin","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Infection, and Immunity Harvard School of Dental Medicine  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas P.","family":"Sollecito","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine University of Pennsylvania School of Dental Medicine  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna","family":"Culton","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of North Carolina at Chapel Hill  Chapel Hill North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aimee S.","family":"Payne","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin S.","family":"Greenberg","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine University of Pennsylvania School of Dental Medicine  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"De Rossi","sequence":"additional","affiliation":[{"name":"School of Dentistry The University of North Carolina at Chapel Hill  Chapel Hill North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.116339"},{"issue":"4","key":"e_1_2_8_3_1","first-page":"391","article-title":"Drug therapy of pemphigus vulgaris","volume":"142","author":"Ahmed A. 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