{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:45:34Z","timestamp":1791927934655,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,4,21]],"date-time":"2019-04-21T00:00:00Z","timestamp":1555804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DE014328 [to CWC]"],"award-info":[{"award-number":["R01 DE014328 [to CWC]"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Vitamin D deficiency\/insufficiency is a worldwide public health issue that has been linked to numerous inflammatory disorders, including periodontitis. There is increasing support for a role for adequate vitamin D levels in overall health. Populations with darker skin color have a higher prevalence of vitamin D deficiency\/insufficiency and periodontitis. The purpose of this small pilot study was to investigate the influence of 12\u00a0weeks of 25(OH)D vitamin D supplementation (VDS) on mediators of systemic inflammation in dark\u2010skinned, periodontitis patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A total of 23 patients with moderate to severe periodontitis were randomly assigned to the vitamin D group or placebo group and received intensive single visit scaling and root planning to elicit a systemic inflammatory response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Vitamin D supplementation increased serum 25(OH)D levels approximately 2\u2010fold over baseline levels; moreover, VDS group had reduced peripheral blood CD3 and CD3+CD8+ cytotoxic T lymphocyte (CTLs) counts and reduced pro\u2010inflammatory salivary cytokines. In contrast, VDS group had higher levels of the autophagy\u2010related proteins and other proteins crucial for anti\u2010microbial autophagy in whole blood PBMCs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In conclusion, VDS has multiple benefits for reducing systemic inflammation and promoting induction of autophagy\u2010related proteins related to anti\u2010microbial functions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.13097","type":"journal-article","created":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T03:04:51Z","timestamp":1553569491000},"page":"1403-1413","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["The influence of vitamin D supplementation on local and systemic inflammatory markers in periodontitis patients: A pilot study"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2344-3579","authenticated-orcid":false,"given":"Mohamed M.","family":"Meghil","sequence":"first","affiliation":[{"name":"Department of Periodontics The Dental College of Georgia at Augusta University Augusta Georgia"},{"name":"Department of Oral Biology The Dental College of Georgia at Augusta University Augusta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lance","family":"Hutchens","sequence":"additional","affiliation":[{"name":"Department of Periodontics The Dental College of Georgia at Augusta University Augusta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anas","family":"Raed","sequence":"additional","affiliation":[{"name":"Georgia Prevention Institute Augusta University Augusta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha A.","family":"Multani","sequence":"additional","affiliation":[{"name":"Department of General Dentistry Eastman Institute for Oral Health, University of Rochester Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mythilypriya","family":"Rajendran","sequence":"additional","affiliation":[{"name":"Department of Periodontics The Dental College of Georgia at Augusta University Augusta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haidong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Georgia Prevention Institute Augusta University Augusta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Looney","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology Medical College of Georgia at Augusta University Augusta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Elashiry","sequence":"additional","affiliation":[{"name":"Department of Periodontics The Dental College of Georgia at 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