{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:49:36Z","timestamp":1747187376273,"version":"3.40.5"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T00:00:00Z","timestamp":1558915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008091","name":"Golestan University of Medical Sciences","doi-asserted-by":"publisher","award":["931016207"],"award-info":[{"award-number":["931016207"]}],"id":[{"id":"10.13039\/501100008091","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Periodontitis is an inflammatory disease that is a result of the interaction between pathogenic bacteria and host immune response. Genetic alterations in interleukin\u201010 (IL\u201010) gene may be associated with the increased risk of periodontitis. We investigated the association between genotype and haplotype frequencies of IL\u201010 gene polymorphisms and susceptibility to periodontitis in an Iranian population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this case\u2013control study, a total of 64 patients with periodontitis and 128 healthy subjects were recruited. The PCR\u2010RFLP technique was used to detect IL\u201010 promoter genotypes at the positions of \u20101082 (G\/A), \u2010819 (C\/T), and \u2010592 (C\/A) in association with the susceptibility to severe chronic periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Regarding IL\u201010 \u2010592 (C\/A) and IL\u201010 \u2010819 (C\/T) alleles and genotypes, no significant association was observed between the risk of periodontitis and genotype frequencies. However, the frequency of GG genotype in IL\u201010 \u20101082 (G\/A) polymorphic region was higher in normal subjects and was associated with the decreased risk of periodontitis under recessive model [OR\u00a0=\u00a02.89, 95% CI (0.99\u20138.43), <jats:italic>p<\/jats:italic>\u00a0=\u00a00.039]. Haplotype analysis revealed a significantly higher presence of H7 (AGC; \u2010592\/\u20101082\/\u2010819) [OR\u00a0=\u00a097.74, 95% CI (95.52\u201399.96), <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IL\u201010 \u20101082(G\/A) polymorphism and AGC (\u2010592\/\u20101082\/\u2010819) haplotype could be associated with the susceptibility to chronic periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13114","type":"journal-article","created":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T15:39:10Z","timestamp":1557157150000},"page":"1619-1626","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Association between interleukin\u201010 gene polymorphisms and severe chronic periodontitis"],"prefix":"10.1111","volume":"25","author":[{"given":"Mohaddeseh","family":"Emampanahi","sequence":"first","affiliation":[{"name":"Department of Oral medicine, Dental faculty Babol University of Medical Sciences Babol Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saba","family":"Masoudi Rad","sequence":"additional","affiliation":[{"name":"Dental Research Center Golestan University of Medical Sciences Gorgan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Saghaeian Jazi","sequence":"additional","affiliation":[{"name":"Metabolic Disorders Research Center Golestan University of Medical Sciences Gorgan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nader","family":"Mansour Samaei","sequence":"additional","affiliation":[{"name":"Stem Cell Research Center Golestan University of Medical Sciences Gorgan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasser","family":"Behnampour","sequence":"additional","affiliation":[{"name":"Department of Biostatics, Faculty of Health Golestan University of Medical Sciences Gorgan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9895-8468","authenticated-orcid":false,"given":"Saeed","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Stem Cell Research Center Golestan University of Medical Sciences Gorgan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5926-6071","authenticated-orcid":false,"given":"Elham","family":"Fakhari","sequence":"additional","affiliation":[{"name":"Dental Research Center Golestan University of Medical Sciences Gorgan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2014.01.057"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2012.04.009"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050315"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.10274.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910508401211"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2011.01437.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364119"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0308184"},{"issue":"9","key":"e_1_2_9_10_1","first-page":"60","article-title":"Pathogenesis of periodontitis: Role of cytokines in host response","volume":"29","author":"Deo V.","year":"2010","journal-title":"Dentistry Today"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.25011\/cim.v33i2.12346"},{"issue":"2","key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"920","DOI":"10.4049\/jimmunol.160.2.920","article-title":"Regulation of monocyte IL\u201010 synthesis by endogenous IL\u20101 and TNF\u2010\u03b1: Role of the p38 and p42\/44 mitogen\u2010activated protein kinases","volume":"160","author":"Foey A. 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