{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T21:43:58Z","timestamp":1787867038057,"version":"build-2784847793"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T00:00:00Z","timestamp":1561420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81530033"],"award-info":[{"award-number":["81530033"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371166"],"award-info":[{"award-number":["81371166"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700995"],"award-info":[{"award-number":["81700995"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500875"],"award-info":[{"award-number":["81500875"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500896"],"award-info":[{"award-number":["81500896"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to develop a mouse model predominating in a proliferative response in the articular cartilage of the temporomandibular joints.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Bilateral anterior elevation of occlusion was developed by installing metal tubes onto the incisors of mice with edge\u2010to\u2010edge relation to prevent tooth wear, leading to an increase in the vertical height of the dental occlusion with time. Morphological changes and expression changes in Cyclin D1, Aggrecan, and type II and type X collagen in the mandibular condylar cartilage were detected. In addition, cells were isolated from the mandibular condylar cartilage and exposed to cyclic tensile strain (CTS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with age\u2010matched controls, the tooth length was longer at 3\u00a0weeks, 7\u00a0weeks, and 11\u00a0weeks in BAE mice (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05), with increased condylar cartilage thickness, matrix amount, and cell number (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Compared with the deep zone cells, CTS stimulated the superficial zone cells to express a higher level of proliferating cell nuclear antigen, Cyclin D1, Aggrecan, and type II collagen but a lower level of type X collagen and alkaline phosphatase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Bilateral anterior elevation stimulated the proliferative response in the mandibular condylar cartilage, offering a new therapeutic strategy for cartilage degeneration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13128","type":"journal-article","created":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T16:30:52Z","timestamp":1558974652000},"page":"1589-1599","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Bilateral anterior elevation prosthesis boosts chondrocytes proliferation in mice mandibular condyle"],"prefix":"10.1111","volume":"25","author":[{"given":"Qian","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Oral Anatomy and Physiology and Clinic of Temporomandibular Joint Disorders and Oral and Maxillofacial Pain, The Key Laboratory of Military Stomatology of State and the National Clinical Research Center for Oral Diseases, School of Stomatology The Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010xu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Oral Anatomy and Physiology and Clinic of Temporomandibular Joint Disorders and Oral and Maxillofacial Pain, The Key Laboratory of Military Stomatology of State and the National Clinical Research Center for Oral Diseases, School of Stomatology The Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Oral Anatomy and Physiology and Clinic of Temporomandibular Joint Disorders and Oral and Maxillofacial Pain, The Key Laboratory of Military Stomatology of State and the National Clinical Research Center for Oral Diseases, School of Stomatology The Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010yun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral Anatomy and Physiology and Clinic of Temporomandibular Joint Disorders and Oral and Maxillofacial Pain, The Key Laboratory of Military Stomatology of State and the National Clinical Research Center for Oral Diseases, School of Stomatology The Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mian\u2010jiao","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Oral Anatomy and Physiology and Clinic of Temporomandibular Joint Disorders and Oral and Maxillofacial Pain, The Key Laboratory of Military Stomatology of State and the National Clinical Research Center for Oral Diseases, School of Stomatology The Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao\u2010tian","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Changhai Hospital The Second Military Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral Anatomy and Physiology and Clinic of Temporomandibular Joint Disorders and Oral and Maxillofacial Pain, The Key Laboratory of Military Stomatology of State and the National Clinical Research Center for Oral Diseases, School of Stomatology The Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral Anatomy and Physiology and Clinic of Temporomandibular Joint Disorders and Oral and Maxillofacial Pain, The Key Laboratory of Military Stomatology of State and the National Clinical Research Center for Oral Diseases, School of Stomatology The Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Oral Anatomy and Physiology and Clinic of Temporomandibular Joint Disorders and Oral and Maxillofacial Pain, The Key Laboratory of Military Stomatology of State and the National Clinical Research Center for Oral Diseases, School of Stomatology The Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010dong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oral Anatomy and Physiology and Clinic of Temporomandibular Joint Disorders and Oral and Maxillofacial Pain, The Key Laboratory of Military Stomatology of State and the National Clinical Research Center for Oral Diseases, School of Stomatology The Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi\u2010bin","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Oral Anatomy and Physiology and Clinic of Temporomandibular Joint Disorders and Oral and Maxillofacial Pain, The Key Laboratory of Military Stomatology of State and the National Clinical Research Center for Oral Diseases, School of Stomatology The Fourth Military Medical University Xi'an 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