{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:22:22Z","timestamp":1790742142333,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009570","name":"Srinakharinwirot University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009570","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate (a) oral colonization of <jats:italic>Candida<\/jats:italic> species, especially for non\u2010<jats:italic>albicans Candida<\/jats:italic> species (NACS), in xerostomic postradiotherapy head and neck cancer patients and (b) risk factors affecting their colonization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Subjective and objective dry mouth scores, stimulated salivary flow rates, pH and buffering capacity were measured in 72 xerostomic postradiotherapy head and neck cancer patients. <jats:italic>Candida<\/jats:italic> counts and species identification were performed using oral rinse samples cultured in <jats:italic>Candida<\/jats:italic> Chromagar, followed by polymerase chain reaction and API 20C AUX system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>Candida<\/jats:italic> colonization was observed in 87.5% of subjects, with 80.6% and 48.6% of study population colonized by <jats:italic>C.\u00a0albicans<\/jats:italic> and NACS, respectively. NACS was associated with high objective dry mouth scores, denture use, and females (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.006, .009, and .036, respectively). In addition, <jats:italic>Candida\u00a0glabrata<\/jats:italic> was detected more in females (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.018) and denture wearers (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.026), while <jats:italic>Candida\u00a0tropicalis<\/jats:italic> was associated with high objective dry mouth scores (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.022) and females <jats:italic>(p<\/jats:italic>\u00a0=\u00a0.027). Quantity of <jats:italic>Candida<\/jats:italic> colonization correlated positively with objective dry mouth scores (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.599, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) and negatively with salivary flow rates (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.258, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.041) and pH (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.290, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.022).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>NACS colonization was common in xerostomic head and neck cancer patients. Increased signs of dry mouth, female and dental prostheses may promote NACS colonization.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13151","type":"journal-article","created":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T07:43:12Z","timestamp":1561966992000},"page":"1798-1808","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Oral <i>Candida<\/i> colonization in xerostomic postradiotherapy head and neck cancer patients"],"prefix":"10.1111","volume":"25","author":[{"given":"Supanat","family":"Tarapan","sequence":"first","affiliation":[{"name":"Faculty of Dentistry Srinakharinwirot University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oranart","family":"Matangkasombut","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Research Unit on Oral Microbiology and Immunology, Faculty of Dentistry Chulalongkorn University Bangkok Thailand"},{"name":"Laboratory of Biotechnology Chulabhorn Research Institute Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dunyaporn","family":"Trachootham","sequence":"additional","affiliation":[{"name":"Institute of Nutrition Mahidol University Nakhon Pathom Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanthana","family":"Sattabanasuk","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sineepat","family":"Talungchit","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Srinakharinwirot University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wannaporn","family":"Paemuang","sequence":"additional","affiliation":[{"name":"Chulabhorn Hospital Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tawaree","family":"Phonyiam","sequence":"additional","affiliation":[{"name":"Institute of Nutrition Mahidol University Nakhon Pathom Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orapin","family":"Chokchaitam","sequence":"additional","affiliation":[{"name":"Chonburi Cancer Hospital Chonburi Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"On\u2010ong","family":"Mungkung","sequence":"additional","affiliation":[{"name":"Chonburi Cancer Hospital Chonburi Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6673-8831","authenticated-orcid":false,"given":"Aroonwan","family":"Lam\u2010ubol","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Srinakharinwirot University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix131"},{"key":"e_1_2_8_3_1","first-page":"78","article-title":"Prevalence of Candida species in the oral cavity of patients undergoing head and neck radiotherapy","volume":"3","author":"Azizi A.","year":"2009","journal-title":"Journal of Dental Research, Dental Clinics, Dental Prospects"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mycmed.2013.11.004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-011-1154-4"},{"key":"e_1_2_8_6_1","first-page":"S2:009","article-title":"A literature review of late complications of radiation therapy for head and neck cancers: Incidence and dose response","author":"Bhandare N.","year":"2012","journal-title":"Journal of Nuclear Medicine & Radiation Therapy"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345000790061401"},{"key":"e_1_2_8_8_1","first-page":"01","article-title":"Kodameae ohmeri \u2013 An emerging yeast: Two cases and literature review","volume":"9","author":"Biswal D.","year":"2015","journal-title":"Journal of Clinical and Diagnostic Research"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-55154-3_8"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.2008.00439.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gerinurse.2015.10.014"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2012.11.011"},{"key":"e_1_2_8_14_1","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1128\/jcm.12.3.475-476.1980","article-title":"Quantitative relationships between Candida albicans in saliva and the clinical status of human subjects","volume":"12","author":"Epstein J. 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