{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:59:07Z","timestamp":1791284347995,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T00:00:00Z","timestamp":1568160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Angular cheilitis (AC) is a clinical entity first described in the XIX century, characterized by erythema, rhagades, ulcerations, and crusting of one or both lip commissures and perilabial skin, responsible of an unpleasant and painful discomfort. Aim of this manuscript was to examine and evaluate the therapeutic options actually available for AC. Despite antifungals being the first\u2010line treatment for most of clinicians, very limited scientific evidence supports their reliability, with just two RCTs published between the 70\u2019s and the 80\u2019s. Furthermore, alternative topical treatments, various techniques of occlusal vertical dimension restoration, B\u2010vitamin supplementation, anti\u2010drooling prosthetic device, and photodynamic therapy have been experimented and proposed, mostly in the form of case reports or case series on a small number of individuals. Our group found in 1% isoconazole nitrate (ISN) and 0.1% diflucortolone valerate (DFV) ointment the most consistent AC treatment, due to the broad spectrum of ISN against many species of dermatohpytes and bacteria, and the anti\u2010inflammatory properties displayed by DFV. However, further and well\u2010designed trials on larger samples of patients are needed to assess the differential profile of consistency of the treatments outlined in literature and claimed by the authors of this paper.<\/jats:p>","DOI":"10.1111\/odi.13183","type":"journal-article","created":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T09:54:38Z","timestamp":1567072478000},"page":"1107-1115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Treatment of angular cheilitis: A narrative review and authors\u2019 clinical experience"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8240-5874","authenticated-orcid":false,"given":"Marco","family":"Cabras","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences Oral Medicine Section CIR\u2010Dental School University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Gambino","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences Oral Medicine Section CIR\u2010Dental School University of Turin Turin Italy"},{"name":"Department of Mechanical and Aerospace Engineering Politecnico of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Broccoletti","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences Oral Medicine Section CIR\u2010Dental School University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0218-8292","authenticated-orcid":false,"given":"Giovanni","family":"Lodi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Surgical and Dental Sciences University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo G.","family":"Arduino","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences Oral Medicine Section CIR\u2010Dental School University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1007"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.5114\/pdia.2016.57764"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12629"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12916"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(85)70069-2"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1179\/14653121042930"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1179\/14653120722725"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12055"},{"key":"e_1_2_7_10_1","first-page":"pii:doj_21759","article-title":"\"Angular\" plasma cell cheilitis","volume":"20","author":"Cunha Filho R. 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