{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:47:53Z","timestamp":1790912873992,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T00:00:00Z","timestamp":1571616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the effect of smoking on peptidoglycan recognition protein (PGRP)\u20101 levels in gingival crevicular fluid (GCF) in smokers and non\u2010smokers with chronic periodontitis (CP) following initial periodontal therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>A total of 40 patients with CP (20 smokers (S\u00a0+\u00a0CP) and 20 non\u2010smokers (S\u2010CP)) and 40 subjects with healthy periodontium (20 smokers (S\u00a0+\u00a0PH) and 20 non\u2010smokers (S\u2010PH)), comprising 80 subjects, were included in this study. Baseline GCF samples were obtained from all subjects, and clinical periodontal measurements were recorded. In patients who had received initial periodontal therapy, GCF samples were obtained and all clinical periodontal measurements were recorded again during the 6th\u20138th weeks. GCF PGRP\u20101 levels were analyzed by enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, GCF PGRP\u20101 levels were significantly higher in both groups with CP than in both groups with healthy periodontium, whereas these levels were significantly lower in S\u00a0+\u00a0CP than in S\u2010CP. GCF PGRP\u20101 levels decreased significantly in both CP groups after periodontal therapy, and this reduction was significantly greater in non\u2010smokers than in smokers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Smoking might have a suppressive effect on GCF PGRP\u20101 levels in CP. Initial periodontal therapy is effective in decreasing GCF PGRP\u20101 levels in both smokers and non\u2010smokers with CP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13207","type":"journal-article","created":{"date-parts":[[2019,10,6]],"date-time":"2019-10-06T08:45:39Z","timestamp":1570351539000},"page":"166-172","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The effect of smoking on gingival crevicular fluid peptidoglycan recognition protein\u20101 level following initial periodontal therapy in chronic periodontitis"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1518-4159","authenticated-orcid":false,"given":"Meltem","family":"Karsiyaka Hendek","sequence":"first","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Kirikkale University Kirikkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8131-6810","authenticated-orcid":false,"given":"Ucler","family":"Kisa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Medicine Kirikkale University Kirikkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7298-8589","authenticated-orcid":false,"given":"Ebru","family":"Olgun","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Kirikkale University Kirikkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060431"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.120666"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411970080040501"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.8.1338"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034512470691"},{"issue":"2","key":"e_1_2_9_8_1","first-page":"119","article-title":"Antimicrobial peptides in the oral environment: Expression and function in health and disease","volume":"7","author":"Dale B. 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