{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T18:40:51Z","timestamp":1778524851521,"version":"3.51.4"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T00:00:00Z","timestamp":1574294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003715","name":"Korea Research Institute of Bioscience and Biotechnology","doi-asserted-by":"publisher","award":["KGM5251911"],"award-info":[{"award-number":["KGM5251911"]}],"id":[{"id":"10.13039\/501100003715","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study was designed to investigate whether necroptosis is involved in the pathogenesis of chemoradiation\u2010induced oral mucositis in a murine model and whether 1\u2010palmitoyl\u20102\u2010linoleoyl\u20103\u2010acetyl\u2010rac\u2010glycerol (PLAG) ameliorates this disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A chemoradiation\u2010induced oral mucositis model was established by treating mice with concurrent 5\u2010fluorouracil (100\u00a0mg\/kg, i.p.) and head and neck X\u2010irradiation (20\u00a0Gy). Phosphate\u2010buffered saline or PLAG (100\u00a0mg\/kg or 250\u00a0mg\/kg, p.o.) was administered daily. Body weights were recorded daily, and mice were sacrificed on Day 9 for tongue tissue analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>On Day 9, chemoradiotherapy\u2010treated (ChemoRT) mice had tongue ulcerations and experienced significant weight loss (Day 0:26.18\u00a0\u00b1\u00a01.41\u00a0g; Day 9:19.44\u00a0\u00b1\u00a03.26\u00a0g). They also had elevated serum macrophage inhibitory protein 2 (MIP\u20102) (control: 5.57\u00a0\u00b1\u00a03.49\u00a0pg\/ml; ChemoRT: 130.14\u00a0\u00b1\u00a0114.54\u00a0pg\/ml) and interleukin (IL)\u20106 (control: 198.25\u00a0\u00b1\u00a016.91\u00a0pg\/ml; ChemoRT: 467.25\u00a0\u00b1\u00a0108.12\u00a0pg\/ml) levels. ChemoRT\u2010treated mice who received PLAG exhibited no weight loss (Day 0:25.78\u00a0\u00b1\u00a01.04\u00a0g; Day 9:26.46\u00a0\u00b1\u00a01.68\u00a0g) and had lower serum MIP\u20102 (4.42\u00a0\u00b1\u00a04.04\u00a0pg\/ml) and IL\u20106 (205.75\u00a0\u00b1\u00a030.41\u00a0pg\/ml) levels than ChemoRT\u2010treated mice who did not receive PLAG. Tongue tissues of mice who received PLAG also displayed lower phosphorylation levels of necroptotic signalling proteins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>1\u2010Palmitoyl\u20102\u2010linoleoyl\u20103\u2010acetyl\u2010rac\u2010glycerol mitigated chemoradiation\u2010induced oral mucositis by modulating necroptosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13224","type":"journal-article","created":{"date-parts":[[2019,11,2]],"date-time":"2019-11-02T01:14:54Z","timestamp":1572657294000},"page":"111-121","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["1\u2010Palmitoyl\u20102\u2010linoleoyl\u20103\u2010acetyl\u2010rac\u2010glycerol ameliorates chemoradiation\u2010induced oral mucositis"],"prefix":"10.1111","volume":"26","author":[{"given":"Solji","family":"Choi","sequence":"first","affiliation":[{"name":"Division of Systems Biology and Bioengineering Cell Factory Research 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