{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T06:39:36Z","timestamp":1759991976850,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T00:00:00Z","timestamp":1574726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Burning mouth syndrome (BMS) is a chronic intraoral burning sensation with no identifiable causes. In this study, we aim to demonstrate the effectiveness of treatment strategy using ethyl loflazepate monotherapy or in combination with milnacipran or amitriptyline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A hospital\u2010based, retrospective study was conducted in 86 patients. The patients were divided into remission group and non\u2010remission group. The remission group comprised patients who were satisfied with their pain relief within a year of treatment initiation and did not require any follow\u2010up treatment. The treatment was considered effective if the patient got remission within 1\u00a0year or was able to reduce the visual analogue scale (VAS) score to &lt;20, in the absence of remission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The treatment strategy was effective in 76.7% of the patients. Significant reductions (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) in VAS scores from 73.5\u00a0\u00b1\u00a014.2 at first visit to 14.7\u00a0\u00b1\u00a08.7 at last visit in the remission group, and from 79.7\u00a0\u00b1\u00a014.3 at first visit to 33.4\u00a0\u00b1\u00a023.7 after 1\u00a0year of treatment in the non\u2010remission group were noted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The treatment strategy using ethyl loflazepate monotherapy or in combination with milnacipran or amitriptyline can be very effective in reducing pain in BMS patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13226","type":"journal-article","created":{"date-parts":[[2019,11,9]],"date-time":"2019-11-09T10:39:35Z","timestamp":1573295975000},"page":"193-199","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Pharmacotherapy in relieving the symptoms of burning mouth syndrome: A 1\u2010year follow\u2010up study"],"prefix":"10.1111","volume":"26","author":[{"given":"Durga","family":"Paudel","sequence":"first","affiliation":[{"name":"Division of Oral Medicine and Pathology Department of Human Biology and Pathophysiology School of Dentistry Health Sciences University of Hokkaido Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Utsunomiya","sequence":"additional","affiliation":[{"name":"Division of Oral Medicine and Pathology Department of Human Biology and Pathophysiology School of Dentistry Health Sciences University of Hokkaido Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koki","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Division of Oral Medicine and Pathology Department of Human Biology and Pathophysiology School of Dentistry Health Sciences University of Hokkaido Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarita","family":"Giri","sequence":"additional","affiliation":[{"name":"Division of Periodontology and Endodontology Department of Oral Rehabilitation School of Dentistry Health Sciences University of Hokkaido Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Uehara","sequence":"additional","affiliation":[{"name":"Division of Disease Control and Molecular Epidemiology Department of Oral Growth and Development School of Dentistry Health Sciences University of Hokkaido Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Division of Disease Control and Molecular Epidemiology Department of Oral Growth and Development School of Dentistry Health Sciences University of Hokkaido Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itsuo","family":"Chiba","sequence":"additional","affiliation":[{"name":"Division of Disease Control and Molecular Epidemiology Department of Oral Growth and Development School of Dentistry Health Sciences University of Hokkaido Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9498-3014","authenticated-orcid":false,"given":"Akira","family":"Toyofuku","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Dentistry Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6358-8508","authenticated-orcid":false,"given":"Yoshihiro","family":"Abiko","sequence":"additional","affiliation":[{"name":"Division of Oral Medicine and Pathology Department of Human Biology and Pathophysiology School of Dentistry Health Sciences University of Hokkaido Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,26]]},"reference":[{"volume-title":"Fact Sheets International Association for Study of Pain","year":"2016","author":"Burning Mouth Syndrome","key":"e_1_2_8_2_1"},{"issue":"10","key":"e_1_2_8_3_1","first-page":"1573","article-title":"Ethyl loflazepate: A prodrug from the benzodiazepine series designed to dissociate anxiolytic and sedative activities","volume":"35","author":"Chambon J. 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