{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:39:56Z","timestamp":1787668796654,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T00:00:00Z","timestamp":1574640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570975"],"award-info":[{"award-number":["81570975"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008233","name":"School of Medicine, Shanghai Jiao Tong University","doi-asserted-by":"publisher","award":["CBXJ201808"],"award-info":[{"award-number":["CBXJ201808"]}],"id":[{"id":"10.13039\/501100008233","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We determined the bacterial community structure of the buccal mucosa in patients with oral lichen planus (OLP) and evaluated the potential association of <jats:italic>Fusobacterium nucleatum<\/jats:italic> with OLP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>We collected buccal mucosal swab samples of patients with OLP (<jats:italic>n<\/jats:italic>\u00a0=\u00a020) and healthy controls (<jats:italic>n<\/jats:italic>\u00a0=\u00a010) and performed 16S rRNA gene sequencing and real\u2010time PCR to determine potentially different bacteria. Damaged and adjacent non\u2010damaged mucosal swab samples of 25 OLP patients were used to detect the amount of <jats:italic>F.\u00a0nucleatum<\/jats:italic> by real\u2010time PCR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with healthy controls, enrichment of <jats:italic>Fusobacterium<\/jats:italic> and <jats:italic>Granulicatella<\/jats:italic> was more abundant in patients with OLP (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.0146 and 0.0034). The abundance of <jats:italic>Fusobacterium<\/jats:italic> and <jats:italic>F.\u00a0nucleatum<\/jats:italic> was significantly enriched on buccal mucosa of patients with OLP compared with healthy controls (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.0043 and 0.0235). Compared with adjacent non\u2010damaged buccal mucosa of OLP patients, the amount of <jats:italic>F.\u00a0nucleatum<\/jats:italic> in the damaged mucosa was significantly increased (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.001). We examined third\u2010level KEGG pathways for bacteria on mucosal surface and found that genes controlling sporulation and ether lipid metabolism were enriched in patients with OLP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A high amount of <jats:italic>F.\u00a0nucleatum<\/jats:italic> may be associated with OLP. Further studies are required to investigate the precise association of <jats:italic>F.\u00a0nucleatum<\/jats:italic> with OLP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13232","type":"journal-article","created":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T18:55:18Z","timestamp":1573498518000},"page":"122-130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Potential association between <i>Fusobacterium nucleatum<\/i> enrichment on oral mucosal surface and oral lichen planus"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5565-8657","authenticated-orcid":false,"given":"Guan\u2010huan","family":"Du","sequence":"first","affiliation":[{"name":"Department of Oral Medicine Shanghai Ninth People's Hospital College of Stomatology Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Shanghai Ninth People's Hospital College of Stomatology Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010jun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Shanghai Ninth People's Hospital College of Stomatology Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010wen","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Shanghai Ninth People's Hospital College of Stomatology Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010zhe","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases The Forsyth Institute Cambridge MA"},{"name":"Harvard School of Dental Medicine Department of Oral Medicine, Infection and Immunity Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo\u2010yao","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Shanghai Ninth People's Hospital College of Stomatology Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.03.012"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-016-1667-2"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1099\/ijsem.0.001339"},{"issue":"6","key":"e_1_2_9_5_1","first-page":"61","article-title":"Metronidazole treatment of the erosive ulcerative form of lichen ruber planus of the oral mucosa","volume":"60","author":"Antonova T. 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