{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:38:30Z","timestamp":1774312710527,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T00:00:00Z","timestamp":1578268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Taste disturbance is a symptom of primary Sj\u00f6gren's syndrome (pSS) of unknown aetiology. This study's objectives were (a) to compare taste function in pSS vs. healthy subjects; (b) to establish whether there is an association between the taste acuity and oral dryness and\/or the neurosensory threshold; and (c) to assess the impact of taste dysfunction on the quality of life (QoL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>This study was conducted on 65 pSS females and 62 healthy volunteers. The gustatory function was tested with taste strips test. Visual analogue scale was used for self\u2010assessment of taste function. The electrogustometer was used to assess the neurosensory threshold. The oral dryness was assessed by the Clinical Oral Dryness Score, salivary flow rate and Xerostomia Inventory. The general and oral health\u2010related QoL and mental health well\u2010being were assessed using validated questionnaires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The pSS group had significantly impaired taste function, but this was not correlated with oral dryness. There was an association between taste acuity and the neurosensory threshold (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a0\u22120.5, 95% CI\u00a0=\u00a0\u22120.2 to \u22120.1). The QoL was not impacted by taste dysfunction (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a0.5).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results suggest that taste impairment in pSS is associated with neurosensory dysfunction and is unlikely to be due to oral dryness.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.13259","type":"journal-article","created":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T17:47:16Z","timestamp":1576777636000},"page":"688-695","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Is the taste acuity affected by oral dryness in primary Sj\u00f6gren\u2019s syndrome patients?"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0432-8615","authenticated-orcid":false,"given":"Minan","family":"Al\u2010Ezzi","sequence":"first","affiliation":[{"name":"Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid","family":"Khan","sequence":"additional","affiliation":[{"name":"Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5370-2423","authenticated-orcid":false,"given":"Anwar R.","family":"Tappuni","sequence":"additional","affiliation":[{"name":"Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2016.1249538"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh170"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00269802"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1991.01870170065015"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200310000-00003"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2007.03.004"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2011.00891.x"},{"issue":"1","key":"e_1_2_8_9_1","first-page":"43","article-title":"Observational studies in epidemiology (STROBE)","volume":"125","author":"Fernandez E.","year":"2005","journal-title":"Med Clin (Barc)"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-2113.85689"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1601858"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-76-3-375"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-010-0329-z"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000006384"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep249"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/25.3.331"},{"key":"e_1_2_8_17_1","first-page":"1333","article-title":"Sjogren's syndrome\u2010associated neuropathy","volume":"65","author":"Koike H.","year":"2013","journal-title":"Brain Nerve"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.2004.00114.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2004.01384.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.3.390"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1993.tb18343.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345820610100901"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2004.01.005"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2012.05.009"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01600"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11020264"},{"key":"e_1_2_8_27_1","doi-asserted-by":"crossref","first-page":"278","DOI":"10.4103\/aian.AIAN_116_17","article-title":"Clinical spectrum, therapeutic outcomes, and prognostic predictors in Sjogren's syndrome\u2010associated neuropathy","volume":"20","author":"Sivadasan A.","year":"2017","journal-title":"Annals of Indian Academy of Neurology"},{"key":"e_1_2_8_28_1","volume-title":"Measuring Oral Health and Quality of Life","author":"Slade G. 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